KOKRISTALISASI ASPIRIN DAN ASAM TARTRAT DENGAN METODE PENGUAPAN PELARUT
DOI:
https://doi.org/10.36465/jop.v4i3.793Keywords:
Kokristal, aspirin, asam tartat, penguapan pelarut, disolusi.Abstract
Telah dilakukan upaya kokristalisasi aspirin dengan asam tartat sebagai koformer. Penelitian ini bertujuan untuk meningkatkan disolusi aspirin (ASP) karena termasuk ke dalam BCS kelas II yang memiliki permeabilitas yang tinggi dan kelarutan yang rendah. Pembentukan kokristal ASP dan asam tartat dibuat dengan perbandingan molar 1:1, 1:2, dan 2:1 dengan menggunakan metode penguapan pelarut. Padatan yang diperoleh kemudian karakterisasi menggunakan powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC) dan Spektrofotometri fourier transform infra red (FTIR). Berdasarkan hasil spektrum FTIR tidak terjadi pergeseran spektrum antara gugus fungsi ASP baku dengan padatan hasil kokristalisasi. Termogram DSC menunjukkan tidak terjadi perubahan perilaku termal antara padatan hasil kokristal dengan ASP baku. Hasil analisis difraktogram PXRD menunjukkan bahwa tidak terdapat puncak baru atau pola difraktogram yang berbeda dibandingkan dengan ASP baku sehingga dapat disimpulkan tidak terbentuk fase kokristal. Hasil uji disolusi pada padatan kokristalisasi 1:1 mampu menaikan laju disolusi 78,56% pada menit ke- 30 dibandingkan dengan ASP baku. Peningkatan laju disolusi pada perbandingan rasio molar 1:1 disebabkan karena terjadi pembentukan campuran eutektik antara ASP dan asam tartat.
References
Batisai, E., Ayamine, A., Kilinkissa, O. E. Y., & Báthori, N. B. (2014). Melting point-solubility-structure correlations in multicomponent crystals containing fumaric or adipic acid. CrystEngComm, 16(43), 9992–9998. https://doi.org/10.1039/c4ce01298d
Cheney, M. L., Weyna, D. R., Shan, N., Hanna, M., Wojtas, L., & Zaworotko, M. J. (2011). Coformer Selection in Pharmaceutical Cocrystal Development: a Case Study of a Meloxicam Aspirin Cocrystal That Exhibits Enhanced Solubility and Pharmacokinetics. Journal of Pharmaceutical Sciences, 100(6), 2172–2181. https://doi.org/https://doi.org/10.1002/jps.22434.
Darwish, S., Zeglinski, J., Krishna, G. R., Shaikh, R., Khraisheh, M., Walker, G. M., & Croker, D. M. (2018). A New 1:1 Drug-Drug Cocrystal of Theophylline and Aspirin: Discovery, Characterization, and Construction of Ternary Phase Diagrams. Crystal Growth and Design, 18(12), 7526–7532. https://doi.org/10.1021/acs.cgd.8b01330
Dutt, B., Choudhary, M., & Budhwar, V. (2021). Preparation, characterization and evaluation of fenofibrate: benzoic acid cocrystals with enhanced pharmaceutical properties. Future Journal of Pharmaceutical Sciences, 7(1). https://doi.org/10.1186/s43094-021-00320-5
Fadhila, M., Umar, S., & Zaini, E. (2020). Pembentukan Kokristal Asam Usnat – N-Methyl-DGlucamine dengan Metode Penguapan Pelarut dan Pengaruhnya terhadap Penurunan Interleukin-8 pada Tikus Inflamasi. Jurnal Sains Farmasi & Klinis, 7(1), 23. https://doi.org/10.25077/jsfk.7.1.23-30.2020
Fuster, V., & Sweeny, J. M. (2011). Aspirin: A historical and contemporary therapeutic overview. Circulation, 123(7), 768–778. https://doi.org/10.1161/CIRCULATIONAHA.110.963843
Haeria, Nurzak, A. N., & Ismail, I. (2015). Characterization and dissolution test of aspirin-nicotinamide cocrystal. International Journal of PharmTech Research, 8(10), 166–170.
Hiendrawan, S., Veriansyah, B., Widjojokusumo, E., Soewandhi, S. N., Wikarsa, S., & Tjandrawinata, R. R. (2016). Physicochemical and mechanical properties of paracetamol cocrystal with 5-nitroisophthalic acid. International Journal of Pharmaceutics, 497(1–2), 106–113. https://doi.org/10.1016/j.ijpharm.2015.12.001
Indra, Azhariyah, P. F., & Aryani, R. (2020). Cocrystallization of Mefenamin Acid and Ascorbic Acid by the Solvent Evaporation Method. 26, 49–52. https://doi.org/10.2991/ahsr.k.200523.014
Indra, I., Fauzi, A., & Aryani, R. (2019). Karakterisasi dan Uji Disolusi Aspirin Hasil Rekristalisasi Penguap Pelarut. Jurnal Sains Farmasi & Klinis, 6(2), 164. https://doi.org/10.25077/jsfk.6.2.164-170.2019
Indra, I., Janah, F. M., & Aryani, R. (2019). Enhancing the Solubility of Ketoconazole via Pharmaceutical Cocrystal. Journal of Physics: Conference Series, 1179(1). https://doi.org/10.1088/1742-6596/1179/1/012134
Linda, D. O. (2012). Universitas Indonesia Universitas Indonesia Jakarta. Fmipa Ui, 1–95.
Motan, G., & Puia, A. (2014). Studies of different types of aspirin by spectrophotometric methods. Acta Chemica Iasi, 22(2), 155–164. https://doi.org/10.2478/achi-2014-0013
Nugraha, Y. P., & Uekusa, H. (2018). Suppressed hydration in metoclopramide hydrochloride by salt cocrystallisation. CrystEngComm, 20(19), 2653–2662. https://doi.org/10.1039/c8ce00129d
Partogi H, T., Soewandhi, S. N., Pamudji, J. S., & Wikarsa, S. (2014). Preparasi Dan Karakterisasi Polimorfisme Obat Anti Malaria Artesunate. Jurnal Sains Materi Indonesia, 15(Vol 15, No 2: JANUARI 2014), 88–94. http://jurnal.batan.go.id/index.php/jsmi/article/view/4362
Rekdal, M., pai, A., & BS, M. (2018). Experimental data of co-crystals of Etravirine and L-tartaric acid. Data in Brief, 16, 135–140. https://doi.org/10.1016/j.dib.2017.11.019
Sarcevica, I., Orola, L., Veidis, M. V., Podjava, A., & Belyakov, S. (2013). Crystal and molecular structure and stability of isoniazid cocrystals with selected carboxylic acids. Crystal Growth and Design, 13(3), 1082–1090. https://doi.org/10.1021/cg301356h
Semalty, A., Semalty, M., Singh, D., & Rawat, M. S. M. (2010). Development and Characterization of Aspirin-Phospholipid Complex for Improved Drug Delivery. International Journal of Pharmaceutical Sciences and Nanotechnology, 3(2), 940–947. https://doi.org/10.37285/ijpsn.2010.3.2.7
Variankaval, N., Wenslow, R., Murry, J., Hartman, R., Helmy, R., Kwong, E., Clas, S. D., Dalton, C., & Santos, I. (2006). Preparation and solid-state characterization of nonstoichiometric cocrystals of a phosphodiesterase-IV inhibitor and L-tartaric acid. Crystal Growth and Design, 6(3), 690–700. https://doi.org/10.1021/cg050462u
Zaini, E., Fitriani, L., Sari, R. Y., Rosaini, H., Horikawa, A., & Uekusa, H. (2019). Multicomponent Crystal of Mefenamic Acid and N-Methyl-D-Glucamine: Crystal Structures and Dissolution Study. Journal of Pharmaceutical Sciences, 108(7), 2341–2348. https://doi.org/10.1016/j.xphs.2019.02.003
