Study In Silico of Apigenin Compounds From Celery as an Antituberculosis Candidate

Abstract

Tuberculosis (TB) is a chronic disease caused by Mycobacterium tuberculosis. The purpose of this study was to determine the interaction of the apigenin compound in celery against the 2WTA receptor in silico. The methods used are molecular anchoring and virtual screening. The results of the apigenin compound showed that the apigenin compound could bind to the 2WTA receptor with the binding affinity value of the apigenin compound -3.68 while the binding affinity value of the native ligand was -3.77. These results illustrate that apigenin compounds are more effective in the treatment of tuberculosis than their natural ligands. So that apigenin compounds have activity as antituberculosis