Sintesis, Karakterisasi dan Penambatan Molekul Bis-2-Chloro-N- (Methylcarbamothioyl)-Benzamide-Iron (III) Sebagai Kandidat Anti Kanker

Ruswanto Ruswanto

Abstract


In drug discovery research and development, modification of an organic compound with metal can increase pharmacological activity. Objective: To synthesize, characterize the Bis-2-Chloro-N- (Methylcarbamothioyl)-Benzamide-Iron (III) complex compound and its interaction with the Ribonucleotide Reductase target receptor. Objective: To synthesize, characterize the Bis-2-Chloro-N- (Methylcarbamothioyl)-Benzamide-Iron (III) complex compound and its interaction with the Ribonucleotide Reductase target receptor. Methods: Synthesis by reflux method with heating, characterization with HSM, UV-vis, FT-IR and MS. Docking was carried out to test the interaction at the ribonucleotide reductase receptor. Results: The weight of the synthetic compound produced was 291.5 mg. Bis-(2-Chloro-N-(Methylcarbamothioyl)-Benzamide)-Iron(III) complex compounds can interact with Ribonucleotide Reductase receptors and are predicted to have better activity than 2-Chloro-N- (Methylcarbamothioyl)-Benzamide compounds with a value of Gibbs free energy (ΔG)/binding affinity - 6.67 kcal/mol and the value of the inhibition constant is 12.85 μM. Conclusion: Bis-2-Chloro-N- (Methylcarbamothioyl)-Benzamide-Iron (III) complex is predicted to be used as an anticancer candidate.

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References


Akhrorov, A. Y., Kuznetsova, E. S.,

Aksenov, S. M., Berdonosov, P. S.,

Kuznetsov, A. N., & Dolgikh, V. A.

Synthesis and crystal structure

of Fe[(Te1.5Se0.5)O5]Cl, the first iron

compound with selenate(IV) and

tellurate(IV) groups. Solid State

Sciences, 74(Iv), 37–43.

https://doi.org/10.1016/j.solidstatescie

nces.2017.10.004

American Cancer Society. 2018. Cancer

Facts & Figures, American Cancer

Society Inc.

Darmapatni, K. A. G., Basori, A., & Suaniti,

N. M. 2016. Pengembangan Metode

Gc-Ms Untuk Penetapan Kadar

Acetaminophen Pada Spesimen

Rambut Manusia. Jurnal Biosains

Pascasarjana, 18(3), 1–13.

Kementrian Kesehatan RI. 2019. Hari

Kanker Sedunia 2019.

https://www.depkes.go.id/article/view/

/hari-kankersedunia

[diakses tanggal 25 Desember 2019].

Mardianingrum, R., Susanti, Ruswanto, R.

Bis(N′-(3-chlorobenzoyl)

isonico-tinohy-drazide) iron (III)

Complex. Molbank 2020, 2020,

M1101.

https://doi.org/10.3390/M1101.

Ningtyas, A. P., & Martak, F. 2013. Sintesis

dan Uji Toksisitas Kompleks Kobalt(II)

dengan Ligan (6E)-(N2)-((E)-2-(6-

aminopiridin- 2-ilimino)-1,2-

difeniletilidin)piridin-2,6- diamina.

Journal of Chemical Information and

Modeling, 53(9), 1689–1699.

https://doi.org/10.1017/CBO97811074

004

Renuka, M. K., & Gayathri, V. 2018.

UV/solar light induced photocatalytic

degradation of phenols and dyes by

Prosiding Seminar Nasional Diseminasi Penelitian

Program Studi S1 Farmasi 2021

STIKes BTH Tasikmalaya

Tasikmalaya, 30 September 2021

ISBN: 978-623-6442-47-0

Fe(PS-BBP)Cl3. Journal of

Photochemistry and Photobiology A:

Chemistry, 353, 477–487.

https://doi.org/10.1016/j.jphotochem.2

12.012.

Rohman. 2014. Spektroskopi Inframerah

dan Kemometrika untuk Analisis

Farmasi. Yogyakarta: Pustaka Pelajar

Ruswanto et al. 2017. Molecular docking of

-benzoyl-3-methylthiourea as anti

cancer candidate and its absorption,

distribution, and toxicity prediction,

Journal of Pharmaceutical Sciences

and Research, 9(5), pp. 680–684.

Ruswanto and Nugraha, A. 2015. Sintesis

Senyawa 1-(4-Hephtilbenzoil-3-

Metiltiourea) Dan Uji Sitotoksisitas

Terhadap Sel T47d Sebagai Kandidat

Antikanker’, 14, pp. 145–153.

Ruswanto, R., Garna, I. M., Tuslinah, L.,

Mardianingrum, R., Lestari, T., &

Nofianti, T. 2018. Kuersetin,

Penghambat Uridin 5-Monofosfat

Sintase Sebagai Kandidat Antikanker. ALCHEMY Jurnal Penelitian

Kimia, 14(2), 236.

https://doi.org/10.20961/alchemy.14.2

.14396.236-254.

Ruswanto R., Mardianingrum R.,

Siswandono S., Kesuma D. 2020.

Reverse docking, molecular docking,

absorption, distribution, and toxicity

prediction of artemisinin as an antidiabetic candidate, Molekul, 15 (2):

–96.

Saleh, Wahidin. 2015. Studi Hubungan

Kuantitatif Struktur- Aktivitas Antituberkulosis Senyawa Amidasi Etil pmetoksisinamat Dengan Pendekatan

Hansch dan Penambatan Molekuler

pada Enzim Inh A. UIN Syarif

Hidayatullah Jakarta.

Sari, N., Rachma, R., & Santi, S. 2017.

Potensi Zat Warna dari Ekstrak

Etanol Kayu Sappang Sebagai

KalorimetriAnion. Al-Kimia, 5(2), 136–

https://doi.org/10.24252/alkimia.v5i2.3540

World Health Organization. 2018. Lates

Global Cancer Data, International

Agency for Research on Cancer, pp.

–15.

Yualanda, V. G., Sary, I. P., & Pangaribowo,

D. A. (2018). Sintesis dan Uji Aktivitas

Antibakteri Senyawa N-Fenil-3,4-

Diklorobenzamida (Synthesis and

Antibacterial Activity Assay of NPhenyl-3,4-Dichlorobenzamide).

Pustaka Kesehatan, 6(1), 5.

https://doi.org/10.19184/pk.v6i1.6610

Zaini, E. et al. 2010. Karakterisasi

Fisikokimia Dan Laju Disolusi

Dispersi Padat, J. Ris. Kim


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