Penambatan Senyawa Anti Virus sebagai Anti COVID-19 terhadap Enzim Papain-Like Protease
Abstract
Papain-like protease is a cysteine protease enzym that is effective in inhibitor the covid-19. The purpose of this study was to determine the interaction of antiviral compounds with the papain-like protease enzym in covid-19 with the best bond-free energy value among the antiviral test compounds including ritonavir, ribavirin, remdesivir, oseltamivir, lopinavir, chloroquine, hydroxychloroquine, favipiravir, umifenovir in the research method using AutodockTools, Lipinski testing, visualization using Discovery Studio Visualizer software and molecular dynamics simulations from the docking result of antiviral test compounds against enzym papain-like protease 3E9S the best free energy binding value of the antiviral compound was umifenovir with the lowest binding affinity value of -8.74 kcal/mol from the result of molecular dynamics, there is a match in amino acids and shows stability in the interaction of umifenovir compounds with the papain-like protease enzym umifenovir compounds can be used as anti-covid-19 drugs.References
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