Pembentukan dan Karakterisasi Kokristal Celecoxib Menggunakan Koformer Nikotinamid
Keywords:
curcumin film, chitosan, PVA (polyvinil alcohol)Abstract
Introduction Cocrystals can be used as an approach based on crystal engineering to improve the
specific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs)
that are difficult to dissolve in water. Solubility is also a very important parameter for API development
to obtain good and stable physicochemical and biopharmaceutical properties. Celecoxib is a nonsteroidal anti-inflammatory drug that is included in BCS (Biopharmaceutical Classification System) class II with high permeability and low solubility in water. Nicotinamide has been widely used as a coformer in making cocrystals, because it has a very large opportunity to form cocrystals with various active pharmaceutical ingredients. Objective of this research is to determine the formation, increase solubility and characterization using Hot Stage Microscopy (HSM), Fourier Transform Infra-Red (FTIR),
Differential Scanning Calorimetry (DSC) dan Powder X-ray Diffraction (PXRD). instruments. Method
used is the Solvent Evaporation method. The results of the characterization of the Hot Stage Microscopy (HSM) instrument have a new crystal phase, Fourier Transform Infra-Red (FTIR) whether there is a shift in functional groups in the cocrystal, Differential Scanning Calorimetry (DSC) where the melting point decreases, Powder X-ray Diffraction (PXRD) there is a new peak which indicates a difference in the X-rays. Results of the solubility test and dissolution test showed an increase in the solubility test and an increase in the dissolution test. Conclusion from the characterization results from the HSM, FTIR, DSC and PXRD instruments shows that there are cocrystal characteristics from each instrument result, and there is an increase in solubility and an increase in the dissolution test of pure celecoxib.
References
Arslan, A., Yet, B., Nemutlu, E., Akdağ Çaylı, Y., Eroğlu, H., & Öner, L. (2023). Celecoxib Nanoformulations with Enhanced Solubility, Dissolution Rate, and Oral Bioavailability: Experimental Approaches over In Vitro/In Vivo Evaluation. Pharmaceutics, 15(2). https://doi.org/10.3390/pharmaceutics15 020363
BPOM. (n.d.). Badan Pengawasan Obat dan Makanan Republik Indonesia.
Chen, H., Wang, C., Liu, S., & Sun, C. C. (2020). Development of piroxicam mini- tablets enabled by spherical cocrystallization. International Journal of Pharmaceutics, 590.
https://doi.org/10.1016/j.ijpharm.2020.11 9953
Li, A., Li, S., Wang, J., Chen, Y., & Lu, M.
(2023). Pterostilbene-Nicotinamide Cocrystal: A Case Report of Single Cocrystals Grown from Melt Microdroplets. Crystal Growth and Design, 23(1), 6–10.
https://doi.org/10.1021/acs.cgd.2c01073
Salma, U. K. (2021). Review Artikel :Peningkatan Kelarutan Atorvastatin Dengan BErbagai Metode Dispersi Padat. Jurnal Ilmiah Farmasi Farmasyifa, 4(1), 6–16. https://doi.org/10.29313/jiff.v4i1.6768
