Pembuatan Film Kitosan - PVA Untuk Meningkatkan Penghantaran Zat Aktif Kurkumin
Keywords:
curcumin film, chitosan, PVA (polyvinil alcohol)Abstract
Curcumin is a bioactive compound with various pharmacological activities, but its use is limited due to its low solubility and stability. Objective: This study aims to design and characterize films containing chitosan and PVA (polyvinyl alcohol) as a delivery system for curcumin. Methods: In this study, curcumin was added to the chitosan-PVA film matrix at concentrations of 0.1%, 0.2%, and 0.3%. The resulting films were tested using FTIR, thickness measurement, in vitro curcumin release, and mechanical properties. Results: Analysis using FTIR indicated interactions among the film components. Thickness testing showed no significant differences among the formulations. In vitro tests indicated that formulation F1 had the best performance, with a curcumin release of 78.08% at pH 6.8 and 25.81% at pH 1.2. Formulation F1 also exhibited an elastic modulus of 0.88 MPa and a mechanical strength of 1.31 MPa.
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