Identifikasi Drug-Related Problems pada Pasien ST-Elevation Myocardial Infarction di RSUD KHZ Musthafa Tasikmalaya
Keywords:
DRPs, STEMI, reaksi obat merugikan, WHO-UMC, CipolleAbstract
ST-Elevation Myocardial Infarction (STEMI) merupakan kondisi kardiovaskular akut yang membutuhkan terapi farmakologis intensif dan kompleks sehingga berisiko menimbulkan Drug Related Problems (DRPs). Penelitian ini bertujuan mengidentifikasi DRPs pada pasien STEMI di RSUD KHZ Musthafa Kabupaten Tasikmalaya. Penelitian ini merupakan studi observasional deskriptif analitik dengan desain retrospektif menggunakan data rekam medis pasien STEMI rawat inap. Sampel berjumlah 96 pasien yang memenuhi kriteria inklusi dan eksklusi. Identifikasi DRPs dilakukan berdasarkan klasifikasi Cipolle et al., sedangkan kausalitas reaksi obat yang merugikan dinilai menggunakan skala WHO-UMC. Data dianalisis secara univariat dan bivariat menggunakan uji chi-square atau Fisher’s exact dengan p<0,05. Hasil menunjukkan pasien didominasi laki-laki sebanyak 79 pasien (82,3%), usia terbanyak 40–49 tahun sebanyak 25 pasien (26,0%), lama rawat inap ≤5 hari sebanyak 88 pasien (91,7%), serta memiliki komorbiditas sebanyak 61 pasien (63,5%). Ditemukan 72 kasus DRPs, dengan kategori terbanyak berupa reaksi obat merugikan sebanyak 33 kasus (45,8%) dan dosis terlalu rendah sebanyak 28 kasus (38,9%). Kausalitas WHO-UMC terbanyak adalah possible sebanyak 21 kasus (63,64%). Jenis kelamin berhubungan bermakna dengan kejadian DRPs (p=0,012; OR=0,168; 95% CI=0,036–0,782).
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