FORMULASI FAST DISINTEGRATING TABLET (FDT) EKSTRAK ETANOL LIDAH BUAYA (Aloe Vera) UNTUK TERAPI GASTRIC ULCER
DOI:
https://doi.org/10.36465/jop.v7i1.1209Abstract
Fast Disintegrating Tablets (FDT) are solid dosage forms that disintegrate very quickly when in contact with saliva. Aloe vera FDT is the development of a herbal product which is expected to increase the speed of neutralization of stomach acid in gastritis. The flavonoid content in aloe vera has pharmacological activity as a stomach protection agent. Apart from that, alkaloids and saponins are able to provide acid neutralization effects. This study aims to determine the effect of the concentration of aloe vera ethanol extract on the physical properties of FDT tablets and the neutralization capacity of stomach acid. Tablets were made using the wet granulation method with aloe vera ethanol extract concentrations of 100 mg/tablet, 125 mg/tablet and 150 mg/tablet. Tablet quality tests carried out include weight uniformity, hardness, friability, disintegration time and stomach acid neutralization test. The data obtained were analyzed using a one-way ANOVA test with a confidence level of 95%. The results showed that increasing the concentration of aloe vera ethanol extract in the FDT preparation was able to reduce friability and increase the neutralization capacity of the preparation. However, differences in the concentration of aloe vera ethanol extract did not have an effect on hardness and disintegration time.
References
Ayensu I, Bekoe SO, Adu JK, Brobbey AA, Appiah A. (2020). Evaluation of acid neutralizing and buffering capacities of selected antacids in Ghana. Scientific African. 2020.8:e00347
Avunduk, C. (2008). Manual of Gastroenterology : Diagnosis and Therapy 4th Edition. Boston: Tufts University Medical School.
[BPOM RI] Badan Pengawas Obat dan Makanan Republik Indonesia. (2019). Penjelasan Bpom Ri Tentang Penarikan Produk Ranitidin Yang Terkontaminasi N-Nitrosodimethylamine (NDMA). Jakarta : BPOM RI
Bala, Rajni, Sushil K, Pravin P. Polymers in Fast Disintegrating Tablets-A Review. Asian Journal of Pharmaceutical and Clinical Research. 2012.5(2), 8-14.
Bhuvana, K. B., Hema, N. G. & Rajesh, P. T., 2014. Review On Aloe Vera. International Journal of Advanced Research, 3(2), 677-691.
British Pharmacopoieia. (2009). British Pharmacopoiea. London: Medicines and Healthcare Products Regulatory Agency (MHRA). hal 6584
Depkes RI. (2020). Farmakope Indonesia Edisi VI. Jakarta : Departemen Kesehatan Republik Indonesia.
Depkes,RI. (2008). Farmakope Herbal Edisi 1. Jakarta : Departemen Kesehatan Republik Indonesia.
[Depkes] Departemen Kesehatan Republik Indonesia. (2000). Parameter Standar Umum Ekstrak Tumbuhan Obat. Jakarta : Departemen Kesehatan Republik Indonesia
[Depkes] Departemen Kesehatan Republik Indonesia. (2014). Farmakope Indonesia. Edisi V. Jakarta : Departemen Kesehatan Republik Indonesia
Citra AE., Fauziah, TS., Zainab, Witasari, HA. (2018). Optimasi Formula Fast Disintegrating Tablet Ekstrak Daun Belimbing Wuluh (Averrhoa Bilimbi L.) dengan Kombinasi Superdisintegrant Crospovidone dan Croscarmellose Sodium. Traditional Medicine Journal. Vol 23(1), 62-69
Dey P, Maiti S. (2010). Orodispersible Tablets: A New Trend In Drug Delivery. J. Nat. Sci. Biol. Med. Vol 1(1), 2-5
Garg A, and Gupta MM. (2013). Review Article Mouth Dissolving Tablets : a Review. J Drug Deliv Ther.3(2), 207–214.
Gibson, N.E. (2014). Efek Hepatoprotektor Ekstrak Etanol Lidah Buaya (Aloe Vera Linn.) Terhadap Gambaran Histopatologi Hati Tikus Jantan Putih (Rattus Norvegicus) Galur Wistar Yang Diinduksi Parasetamol. Skripsi. Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Tanjungpura
Irawan, W., & Sulaiman, T.S. (2016). Optimasi Formula Disintegrating Tablet Natrium Diklofenak Terinklusi B-Siklodekstrin dengan Superdisintegrantt Crospovidone dan Filler Binder Mikrokristalin Selulosa Ph 102. Majalah Farmaseutik. Vol 12(2), 443-452.
Kemenkes RI, Profil Kesehatan Indonesia Tahun 2018, Jakarta: Kementrian Kesehatan Republik Indonesia; 2019.
Kurniawati, D, Jasaputra, DK, Ratnawati, H, dkk. (2010). The Comparison Effect of Aloe vera L., Psidium guajava Linn, Curcuma domestica Val to Colitis Ulcerative Mice Models Histopatology. Jurnal Medika Planta. Vol 1(2), 41-48.
Mohanachandran PS, Sindhumol PG, Kiran TS. (2011). Superdisintegrant:An Overview. International Journal of Pharmaceutical Sciences Review and Research. 2011. 6(1),105-109.
Mota, KSDL, Dias, GEN, Pinto, MEF, dkk. (2009). Flavonoids with Gastroprotective Activity, Molecules. Vol 14, 979-1013.
Movva, B., Kumar, DL, Kumar, KMR. (2013). Formulation and Evaluation of Fast Disintegrating Tablets of Ranitidine Hydrochloride by Hole Technology. Asian Journal of Pharmaceutical and Clinical Reseasrch. Vol 6(4), 143-147
Muñoz, O., Leal, X. & Cardemil, L. (2015). Extraction, Characterization and Properties of the Gel of Aloe Vera ( Aloe barbadensis Miller) Cultivated in Chile. Medicinal & Aromatic Plants, 4(3).
Najib, A., Malik, A, Ahmad, AR, dkk. (2017). Standarisasi Ekstrak Air Daun Jati Belanda Dan Teh Hijau. Jurnal Fitofarmaka Indonesia. Vol. 4 No.2, 241-245.
Pahwa, R. dan Gupta, N. (2011). Superdisintegrants in the Development of Orally Disintegrating Tablets: A Review. J. Pharm. Sci. 2(11), 2767-2780.
Panigrahi, R., dan Behera, S. (2010). A Review on Fast Dissolving Tablets. Webmed Central Quality and Pasien Safety, Vol 1(9)
Raini, M. Dan Isnawati, A. (2009). Penyakit Peptik dan Misoprostol. Jurnal Kefarmasian Indo. Volume 1(3), 4
Rusanti W.D. (2016). Pengaruh Penambahan Lidah Buaya (Aloe vera sp) Terhadap Kekentalan Dan pH Pada Soygurt. KONVERSI. Vol. 5, 2.
Saverio, SD, Bassi M, Smerieri, N, dkk. (2014). Diagnosis and treatment of perforated or bleeding peptic ulcer. World Journal of Emergency Surgery. Aug 3:9:45. doi: 10.1186/1749-7922-9-45.
Shafee MM, Kandasamy R, Abdulgani TO, Shaikh SZ, Kondaguli AV. (2015). “Immediate Release Compositions of Acid Labile Drugs” U.S. Patent No. 8,999,384.7 Apr.2015
Sulaiman, T.N.S. (2007) Teknologi dan Formulasi Sediaan Tablet, Edisi I. Yogyakarta : Pustaka Laboratorium Teknologi Farmasi UGM
Tarigan, P. (2014). Buku ajar ilmu penyakit dalam. Jakarta: Interna Publishing,1781-1791.
Vidic., D, Taric, E, Alagic, J. dkk. (2014). Determination of Total Phenolic Content and Antioxidant Activity of Ethanol Extracts from Aloe spp. Bulletin of the Chemists and Technologists of Bosnia and Herzegovina. Vol 42, 5–10.
Yusuf S., Agunu A.dan Diana M. (2004). The effect of Aloe vera A. Berger (Liliaceae) on gastric acid secretion and acute gastric mucosal injury in rats. Journal of Ethnopharmacology. Vol 93, 33–37.
