FORMULASI FAST DISINTEGRATING TABLET (FDT) EKSTRAK ETANOL LIDAH BUAYA (Aloe Vera) UNTUK TERAPI GASTRIC ULCER

Agus Siswanto, Yunanda Sri Anggrayta

Abstract


Fast Disintegrating Tablets (FDT) are solid dosage forms that disintegrate very quickly when in contact with saliva. Aloe vera FDT is the development of a herbal product which is expected to increase the speed of neutralization of stomach acid in gastritis. The flavonoid content in aloe vera has pharmacological activity as a stomach protection agent. Apart from that, alkaloids and saponins are able to provide acid neutralization effects. This study aims to determine the effect of the concentration of aloe vera ethanol extract on the physical properties of FDT tablets and the neutralization capacity of stomach acid. Tablets were made using the wet granulation method with aloe vera ethanol extract concentrations of 100 mg/tablet, 125 mg/tablet and 150 mg/tablet. Tablet quality tests carried out include weight uniformity, hardness, friability, disintegration time and stomach acid neutralization test. The data obtained were analyzed using a one-way ANOVA test with a confidence level of 95%. The results showed that increasing the concentration of aloe vera ethanol extract in the FDT preparation was able to reduce friability and increase the neutralization capacity of the preparation. However, differences in the concentration of aloe vera ethanol extract did not have an effect on hardness and disintegration time.


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References


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DOI: http://dx.doi.org/10.36465/jop.v7i1.1209

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