UJI TOKSISITAS AKUT EKSTRAK BUAH OKRA (Abelmoschus esculatus L. Moench) TERHADAP PARAMETER KADAR SGOT DAN SGPT SERTA HISTOPATOLOGI HEPAR TIKUS GALUR WISTAR

Maritsa Nurfatwa

Abstract


Okra (Abelmoschus esculatus l. Moench) fruit has been used empirically and scientifically proven to have effect to control  blood cholesterol and blood glucose level. However, there has been no research on okra ethanol extract acute toxicity effect on hepatocyte. This research was aim to evaluate okra ethanol extract acute toxicity on liver using SGOT, SGPT and liver histopathology parameter after given 300 mg/kg bw (1 dose), 2000 mg/kg bw (dose 2) and 5000 mg/kg bw (3 doses) okra ethanol extract to female wistar rats. There were no significant differences on SGOT and SGPT level among all of experiment groups, but SGOT and SGPT increased along with increasing dosage. Histopathology showed no significant damage on hepatocytes. Okra ethanol extract has no acute toxic effect on the liver.

 Keywords: Okra, SGOT, SGPT, histopathology.


Full Text:

PDF

References


Badan Pengawas Obat dan Makanan (BPOM). 2014. Pedoman Uji Toksisitas Nonklinik Secara In Vivo. Jakarta: Kepala Badan Pengawas Obat dan Makanan RI.

Fauziana, A. 2016. Pengaruh Perasan Buah Okra (Abemoschus esculentus L.) Terhadap Kadar Kolesterol Mencit (Mus musculus L) BALB-C dan Pemanfaatannya Sebagai Leaflet. Skripsi. Jember: Universitas Jember.

Kumar, D. 2013. A Review on Abelmoschus Esculentus (Okra). Int. Res J Pharm. App Sci. 3 (4): 129-132.

Roy, A., Shrivastava, S. L., Mandal, S. M. 2014. Functional properties of Okra Abelmoschus esculentus L. (Moench): traditional claims and scientific evidences Plant Science Today. 1 (3): 121-130.

Safitri, N. 2015. Uji Potensi Anti Diabetes Ekstrak Etanol Buah Okra (Abemoschus esculentus L.) pada Mencit Putih Jantan (Mus musculus) yang di Induksi Glukosa. Skripsi. Makasar: UIN Allauddin Makasar.

Utami, A. R., I K. Berata, Samsuri, I M. Merdana. 2017. Efek Pemberian Propolis terhadap Gambaran Histopatologi Hepar Tikus Putih yang diberi Parasetamol. Buletin Veteriner Udayana. Vol. 9 (1): 8793.

Wulandari, T. M. Harini, dan S. Listyawati. 2007. Pengaruh Ekstrak Daun Sambiloto (Andrographis Paniculata) Terhadap Struktur Mikroanatomi Hepar dan Kadar Glutamat Piruvat Transaminase Serum Mencit (Mus Musculus) yang Terpapar Diazinon. Bioteknologi. 4 (2): 53-58.




DOI: http://dx.doi.org/10.36465/jop.v1i2.330

Refbacks

  • There are currently no refbacks.


Copyright (c) 2018 Journal of Pharmacopolium

p-ISSN: 2620-8563; e-ISSN: 2621-1521


Index:

RJI Main logo