PENGARUH EKSTRAK ETANOL DAUN RAMBUTAN (NAPALEUM LAPPACEUM L.) TERHADAP KADAR LDL DAN HDL PADA TIKUS JANTAN
DOI:
https://doi.org/10.36465/jop.v1i3.431Abstract
The leaves of the rambutan (Napaleum lappaceum l.) is alleged to have activity as antihiperlipidemia. This research aims to know the activity of ethanol extract of antihiperlipidemia leaves on animal model of rambutan induced with foods high in carbohydrates and fat. Research methodology used in modeling animal experiments as much as 30 white rats Wistar strain males aged 2-3 months and weight 150-220 grams are grouped into 6 groups , namely the Group of negative control positive control group (Group induction), the standar group (simvastatin 0,9 mg/kgBw) and group test of ethanol extract of rambutan leave with a dose of 17,5, 35 and 70 mg/kgBw. All groups except the negative control induced eating high carbs and fats as food every day for 29 days. The comparison test and extract given every day in per-oral 3 hours after animals induced. The observed parameters i.e. LDL and HDL cholesterol levels specified are enzymatic. From the results of the study showed that ethanol extracts of leaves of herbs against LDL levels and can increase HDL levels at 70 mg/dose KgBB has the same activity with the activity checklist 0.9 mg/dose simvastatin KgBB. It can be concluded that ethanol extracts of leaves of herbs have lower levels of activity in the LDL and increase HDL levels is best with a dose of 70 mg/kgBw.
References
Andi Suhendi, dkk. 2015. Potential Activity of Rambutan (Nephelium lappaceum L.) Fruit Peel Extract as Antidiabetic and Antihypercholesterolemia. Fakultas Pharmasi. Universitas Muhammadiyah Surakarta
Bok, S.H., Lee, S.H., B., Park, Y.B., Bae, K.H., Son,K.H., Jeong, T.S., & Choi, M.S. 1999. Plasma and Hepatic Cholesterol and Hepatic Activities of 3-Hydroxy-3-methyl-glutaryl-CoA Reductase and Acyl CoA: Cholesterol Transferase are Lower in Rats Fed Citrus Peel Extract or a Mixture of Citrus Bioflavonoids. Journal. Nutrition. 129: 1182–1185
Dipiro, Joshep T., Gwells, Barbara., et al. 2015. Pharmacotherapy Handbook 9th Edition. New York : McGraw Hill. Hal 65-74.
Diajeng Galuh, dkk. 2012. Kadar HDL, Kadar LDL dan Gambaran Histopatologi Aorta Pada Hewan Model Tikus (Rattus norvegicus) Hiperkolesterolemia Dengan Terapi Ekstrak Air Benalu Mangga (Dendrophtoe penthandra). Universitas Brawijaya. Malang
Departemen Kesehatan Republik Indonesia. 2008. Profil kesehatan Indonesia 2008. Jakarta: Departemen Kesehatan RI., 60-62.
Herwiyarirasanta., BA, Eduardus.. 2010.. Effect of Black Soyban Extract Supplemen tation in Low Density Lipoprotein Level of Rats (Rattus norvegicus) With High Fat Diet. Science Article Universitas Airlangga. Surabaya
Gina, D. 2016. Aktivitas Ekstrak Etanol Daun Rambutan (Naphelium Lappaceum L.) Sebagai Antidiabetes Pada Mencit yang Di Induksi Aloksan. Skripsi, Sekolah Tinggi Farmasi Bandung.
Muhtadi, dkk. 2013. Pengembangan Potensi Ekstrak Kulit Buah Rambutan Sebagai Bahan Obat Herbal Antihiperkolesterol. Biomedika, Volume 5 Nomor 2.
Riskesdas. 2007. Laporan Hasil Riskesdas Prevalensi Hiperlipidemia di Indonesia.Jakarta: Badan Penelitian dan Pengembangan Kesehatan Departemen Kesehatan
Sukandar,E.Y., Kurniati,N.F., Nurdianti,A.N. 2016. Antiobesity Effect Of Ethanol Extract Of Andredera cordifolia (Ten) Steenis Leaves On Obese Male Wistar Rats Induced By High-Carbohydrate Diet. Internasional Journal Of Pharmacy and Pharmaceutical Sciences. ISSN 0975-1491. Vol 8, Issue 4.
Tabata, H., Katsube, T., Tsuma, T., Ohta, Y., Imawaka, N., dan Utsumi, T. 2008. Isolation and evaluation of the radical-scavenging activity of the antioxidants in the leaves of an edible plant Mallotus japonicus, Food Chemistry.
Waltner-Law M, E., Wang X, L., Law B, K., Hall R, K., Nawano, M. 2002. Epigallocatechin gallate,a constituent of Green tea represses hepatic glucose production. Journal.277(38).
World Health Organization. 2011. Childhood Overweight and Obesity.Available.from:http://www.who.int/dietphysicalactivity/childhood/en.html. (Accessed tanggal 15 Oktober 2016).
World Health Organization. 2010. The World Health Report 2010. http://www.who.int./whr/2010/en/index.html (Akses 18 Oktober 2016)
