IN SILICO STUDY OF FLAVONOID DERIVATIES ON N-METHYLTRANSFERASE HISTAMINE RECEPTOR AS AS ANTI-ALLERGIC

Abstract

Allergies are the most common or chronic disorders. Allergy symptoms can be treated with antihistamines. Antihistamines work by contracting smooth muscle. Flavonoids are secondary metabolites that are used as anti-allergies such as Baikalein and Nobiletin. The purpose of conducting an in silico study of the histamine N-Methyltransferase receptor with code pdb 1jqd complexed with ciproheptadine, is expected from this in silico test to obtain compounds that have more potential. The results of the screening and molecular anchoring simulation process as well as molecular dynamics show that nobiletin and Baikalein compounds can bind and have a stable interaction with the histamine N-Methyltransferase receptor (antiallergic) for the results, namely nobiletin with a binding energy value of -8.16 and baicalein with binding energy - 6.57.