Pengaruh Ekstrak Etanol Daun Singkong (Manihot esculenta Crantz) Terhadap SGPT, SGOT dan Indeks Organ Hati Tikus Putih Jantan Wistar
Abstract
The liver is the largest organ in the body, accounting for about 2% of the total body weight, or about 1.5 kg (3.3 pounds) in the average adult human. The mechanism by which paracetamol overdose causes hepatocellular damage and death involves its conversion to the toxic metabolite NAPQI (NAcetyl-p-Benzoquinonemine). This study aims to determine the effect of ethanol extract of cassava leaves (Manihot esculenta Crantz) on SGPT, SGOT and organ index of male wistar rats induced by Paracetamol. Liver biochemical parameters used were levels of the enzyme SGPT, SGOT and Organ Index. The results of the ethanol extract of cassava leaves (Manihot esculenta Crantz) dose 1 (0.0017g/200g BW rats), dose 2 (0.0035g/200 g BW rats) and dose 3 (0.0071g/200g BW rats) can affect the SGPT enzyme levels, SGOT and Organ Index, where dose 2 (0.0035g/200 g BW rats) with a significance value of LSD follow-up test results of 0.856 in SGPT and 0.057 in SGOT and is the most effective dose in reducing SGPT, SGOT and Organ Index .References
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