Pengaruh Ekstrak Etanol Daun Singkong (Manihot esculenta Crantz) Terhadap SGPT, SGOT dan Indeks Organ Hati Tikus Putih Jantan Wistar
Abstrak
The liver is the largest organ in the body, accounting for about 2% of the total body weight, or about 1.5 kg (3.3 pounds) in the average adult human. The mechanism by which paracetamol overdose causes hepatocellular damage and death involves its conversion to the toxic metabolite NAPQI (NAcetyl-p-Benzoquinonemine). This study aims to determine the effect of ethanol extract of cassava leaves (Manihot esculenta Crantz) on SGPT, SGOT and organ index of male wistar rats induced by Paracetamol. Liver biochemical parameters used were levels of the enzyme SGPT, SGOT and Organ Index. The results of the ethanol extract of cassava leaves (Manihot esculenta Crantz) dose 1 (0.0017g/200g BW rats), dose 2 (0.0035g/200 g BW rats) and dose 3 (0.0071g/200g BW rats) can affect the SGPT enzyme levels, SGOT and Organ Index, where dose 2 (0.0035g/200 g BW rats) with a significance value of LSD follow-up test results of 0.856 in SGPT and 0.057 in SGOT and is the most effective dose in reducing SGPT, SGOT and Organ Index .Referensi
Es-Safi, N.E., S. Guidouche and P.H. Ducrot.
(2007). Flavonoids: Hemisynthesis,
reactivity and antioxidative properties.
Molecules, 12: 2228-2258.
Farida. (2014). Uji Aktivitas Antioksidan
Ekstrak Metanol Daun Singkong
(Manihot esculenta Crantz) Dan FraksiFraksinya Menggunakan Metode
DPPH [Skripsi]. Tasikmalaya. Program
Studi S1 Farmasi STIKes Bakti Tunas
Husada.
Fathoni, F. (2008). Studi Kasus SGPT,
SGOT, dan Total Protein pada Serum
Darah Anjing Kampung (Canis
familiaris) Usia 3 Bulan dan 6 Bulan.
Skripsi. IPB. Bogor
Franswort NR. (1996). Biological and
Phytochemical screening of plain.
Journal of Pharmaceutical Science.
Vol. 5.p: 243 – 269.
Goodman A., and Gilman. (2014). Manual
Farmakologi dan Terapi. Jakarta: Buku
Kedokteran EGC
Guyton A.C, dan Hall, J.E. (2014). Buku Ajar
Fisiologi Kedokteran. Edisi 12.
Penerjemah: Ermita I, Ibrahim I.
Singapura: Elsevier
Hamid, A.A.,Aiyelaagbe, O.O., Usman, L.A,
Ameen, O.M., Lawal, A. (2010).
Antioxidant : its Medidal and
Pharmacological Applications. African
Journal of pure and applied chemistry
vol.4(8), pp. 142- 151
Indonesia, Badan Pengawas Obat dan
Makanan Republik. (2014). Peraturan
Kepala BPOM RI no. 7 Tahun 2014
tentang Pedoman Uji Toksisitas
Nonklinik secara in vivo. Jakarta
Johnston., D.E., and Kroening, C. (1998).
Mechanism of Early Carbon
Tetrachloride Toxicity in Cultured Rat
Hepatocytes. Pharmacology &
Toxicology. 83. 231-239.
Kaplowitz N, DeLeve LD. (2003). Drug
induced liver disease. New York:
Marcel Dekker
Shahidi, F., Kadaswarmi, C., Middleton, E.
Natural Antioxidants: Chemistry,
Health Effects, and Applications. AOCS
Press; Illionis.
Sayuti, K. Rina Y. (2015). Antioksidan Alami
dan Sintetik. Padang: Andalas
University Press.
Seyoum A, Asres K, El-fiky FK. (2006).
Structure-radical scavenging activity
relationships of flavonoids.
Phytochemistry; 67(18):2058-70
Williams, D. A. & Lemke, T.L. (editors).
(2002). Foye’s Principles of Medicinal
Chemistry. 5th Edition. Philadelpia :
Lippincott William & Witkins: 174-233
Winarsi H. (2007). Antioksidan Alami dan
Radikal Bebas. Penerbit Kanisius,
Yogyakarta
