Aktivitas Antidiabetik Ekstrak Serabut Kelapa (Cocos nucifera L.) pada Tikus Galur Wistar

Diani Annisa Agustina, Nur Rahayuningsih, Ruswanto Ruswanto

Abstract


Coconut fruit (Cocos nucifera L.) can be utilized for treatment and beauty because it contains polyphenols, flavonoids, monoterpenes and seskuiterpene, phenolic acid. Several of these phytochemical compounds can function as antioxidants. Objective: This research aims to find out the activity of coconut fiber extract (Cocos nucifera L.) as an antidiabetic and the effective dose as an anti-diabetes. Methods: Coconut fibers was extracted by maceration with 96% ethanol solvent. Antidiabetic activity was Tested by the OGTT (Oral Glucose Tolerance Test) method. (Oral Glucose Tolerance Test). Measurement of blood glucose levels was tested on rats which were divided into 6 groups (normal, negative, positive, dose 1, dose 2 and dose 3), each group consisting of 4 rats. The The analysis uses the SPSS version 16.0 statistical test, namely Paired T Test with the condition that the data must be distributed normally and homogeneous with a 95% confidence level. Results: Based on the difference in the percentage of decrease in blood glucose levels is evidenced through the analysis of statistical using the paired sample T test. Stating, there is a significant difference, which at all doses can decrease blood glucose levels. This indicates the presence of anthocyanins as antioxidants. Conclusion: The results of coconut fiber extract (Cocos nucifera L.) test showed antidiabetic activity. Stating, test doses had antidiabetic activity, with the most effective dose being in dose 2 (500 mg/200 gram BW rats). The percentage of decreased levels at dose 2 is 25,0922%.

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