Aktivitas Antidiabetik Ekstrak Serabut Kelapa (Cocos nucifera L.) pada Tikus Galur Wistar
Abstrak
Coconut fruit (Cocos nucifera L.) can be utilized for treatment and beauty because it contains polyphenols, flavonoids, monoterpenes and seskuiterpene, phenolic acid. Several of these phytochemical compounds can function as antioxidants. Objective: This research aims to find out the activity of coconut fiber extract (Cocos nucifera L.) as an antidiabetic and the effective dose as an anti-diabetes. Methods: Coconut fibers was extracted by maceration with 96% ethanol solvent. Antidiabetic activity was Tested by the OGTT (Oral Glucose Tolerance Test) method. (Oral Glucose Tolerance Test). Measurement of blood glucose levels was tested on rats which were divided into 6 groups (normal, negative, positive, dose 1, dose 2 and dose 3), each group consisting of 4 rats. The The analysis uses the SPSS version 16.0 statistical test, namely Paired T Test with the condition that the data must be distributed normally and homogeneous with a 95% confidence level. Results: Based on the difference in the percentage of decrease in blood glucose levels is evidenced through the analysis of statistical using the paired sample T test. Stating, there is a significant difference, which at all doses can decrease blood glucose levels. This indicates the presence of anthocyanins as antioxidants. Conclusion: The results of coconut fiber extract (Cocos nucifera L.) test showed antidiabetic activity. Stating, test doses had antidiabetic activity, with the most effective dose being in dose 2 (500 mg/200 gram BW rats). The percentage of decreased levels at dose 2 is 25,0922%.Referensi
Afandy, M. A., Nuryanti, S., & Diah, W. M.
(2017). Extraction of Purple Sweet
Potato ( Ipomoea batatas L .) Using
Solvent Variation and Its Utilization as
Acid-Base Indicator. Jurnal Akademika
Kimia, 6(2), 79–85.
Ajie, R. B. (2015). White Drogon Fruit
(Hylocereus undatus) Potential as
Diabetes Melitus Treatment. J
MAJORITY, 4(1), 69–72.
Anggriani, R., Ain, N., & Adnan, S. (2017).
Identifikasi Fitokimia dan Karakterissasi
Antosianin Dari Sabut Kelapa Hijau (
Coconut Nucifera L Var Varidis )
Identification of Phytochemical and
Characterization of Anthocyanin Green
Coconut Fiber ( Cocos nucifera L var
varidis ). Jurnal Teknologi Pertanian,
(3), 163–172.
Anjani, E. P., Oktarlina, R. Z., Morfi, C. W.,
Farmakologi, B., Ilmu, D., Kedokteran,
F., & Lampung, U. (2018). Zat
Antosianin pada Ubi Jalar Ungu
terhadap Diabetes Melitus. 7, 257–262.
Hafizh, I. Al, & Tukiran. (2020). Skrining
Fitokimia Ekstrak Diklorometana Kulit
Batang Tumbuhan Jambu Semarang (
Syzygium samarangense ). 9(1), 49–
Irondi, E. A., Shode, F. O., Afolabi, W. O., &
Boligon, A. A. (2017). In Vitro Inhibitory
Effects of Coconut Husk Extract on
Some Enzymes Relevant to the
Pathogenesis of Obesity, Gout and
Hypertension. Journal of Biologically
Active Products from Nature, 7(5),
–368.
https://doi.org/10.1080/22311866.2017.
Jauziyah, J. U., Purwanti, L., & Syafnir, L.
(2019). Pengujian Potensi Antioksidan
Ekstrak Sabut dan Ampas Daging
Buah Kelapa ( Cocos nucifera L .)
Serta Perbandingannya Terhadap
Virgin Coconut Oil Menggunakan
Metode DPPH. ISSN, 5(2), 1–5.
Kurniawati. (2015). Daya Antibakteri Ekstrak
Etanol Tunas Bambu Apus Terhadap
Bakteri Escherichia Coli dan
Staphylococcus Aureus Secara In
Vitro. Jurnal Wiyata, 2(2), 193–199.
Kurniawati, E., & Sianturi, C. Y. (2016).
Manfaat Sarang Semut (Myrmecodia
pendans) sebagai Terapi Antidiabetes.
Majority, 5(3), 38–42.
Manarisip, G. E., Rotinsulu, H., & Fatimawali.
(2020). Standardization Of Green Betel
Leaf Extracts ( Piper betle L .) and
Antibacterial Test Against
Pseudomonas aeruginosa.
Pharmacon-Program Studi Farmasi,
(November), 533–541.
Priska, M., Peni, N., Carvallo, L., & Ngapa, Y.
D. (2018). Antosianin Dan
Pemanfaatannya. 6, 79–97.
Rahayuningsih, N. (2017). Pengaruh Ekstrak
Etanol Buah Pepino Terhadap Kadar
Ureum Dan Kreatinin Tikus Putih
Jantan. The AAPS Journal, 17(2), 492–
Yuliastri, W. O., Lolok, N. H., Ikawati, N.,
Maghvira, R., & Kunci, K. (2020). Uji
Efek Ekstrak Bawang Hitam ( Allium
sativum ) terhadap Penurunan Kadar
Glikosa Darah pada Tikus Putih (
Rattus novergicus L ) dengan Metode
Tes Toleransi Glukosa Oral ( TTGO )
Test Effect Of Black Garlic ( Allium
sativum ) Extract Againts Decreased
Blo. 1(1), 53–63.
Zalukhu, M. L., Phyma, A. R., & Pinzon, R. T.
(2016). Proses Menua , Stres Oksidatif
, dan Peran Antioksidan. 43(10), 733–
