TINJAUAN SISTEMATIK FARMAKOLOGI DAN TOKSISITAS TANAMAN BANDOTAN (Ageratum conyzoides L.)
DOI:
https://doi.org/10.36465/jkbth.v24i1.1284Keywords:
Ageratum conyzoides, pharmacology, toxicity, systematic reviewAbstract
Ageratum conyzoides is a plant renowned for its medicinal properties since ancient times. However, a thorough systematic review of the pharmacology and toxicity of this plant is still limited and without an explanation of the study stage, such as preclinical or clinical. A literature search was performed on various databases, including Pubmed, Cochrane, Science Direct, and Google Scholar, using specific keywords such as Ageratum conyzoides, Pharmacology, Safety, and Toxicity. The search yielded various pharmacological activities. The clinical stage of the pharmacological study is only for anti-benign prostate hyperplasia activity. However, the activity of anti-microbial, anti-poison, analgesic-antiinflammatory, hemostatic, wound healing, radioprotective, cardioprotective, vasorelaxant, spasmolytic, hematopoietic, anti-hyperglycemic, gastroprotective, insecticidal, hepatoprotective, and anticonvulsant are still in preclinical stages. In toxicity study, In general extract preparations of A.conyzoides is considered safe, however there are concerns about side effects to liver, kidney, hematological, and heart. A. conyzoides has a broad range of pharmacological activities, but there are concerns regarding its safety profiles.
References
Abena AA, Kintsangoula-Mbay GS, Diantama J, Bioka D (1993) Effets analgésiques d'un extrait brut d'Ageratum conyzoïdes chez le rat [Analgesic effects of a raw extract of Ageratum conyzoïdes in the rat]. Encephale 19(4): 329-32. https://pubmed.ncbi.nlm.nih.gov/8275920/
Adebayo AH, Tan NH, Akindahunsi AA, Zeng GZ, Zhang YM (2010) Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae). Pharmacognosy Magazine 6(21): 62-6. DOI : 10.4103/0973-1296.59968
Adetutu A, Morgan WA, Corcoran O (2011) Ethnopharmacological survey and in vitro evaluation of wound-healing plants used in South-western Nigeria. Journal of Ethnopharmacology 137(1): 50-6. DOI: 10.1016/j.jep.2011.03.073
Agunbiade OS, Ojezele OM, Ojezele JO, Ajayi AY (2012) Hypoglycaemic activity of Commelina africana and Ageratum conyzoides in relation to their mineral composition. African Health Sciences 12(2): 198-203. DOI 10.4314/ahs.v12i2.19
Ajayi EO, Awala S, Okogbue NF, Ogunleye GA, Olaleye FB (2016) Antibacterial Efficacy of Ageratum conyzoides on Salmonella Species Isolated from Suspected Typhoid Fever Patients in Akure Metropolis, Nigeria. Journal of Advances in Medical and Pharmaceutical Sciences 6(2): 1-9. DOI: 10.9734/jamps/2016/23307
Akinyemi KO, Oladapo O, Okwara CE, Ibe CC, Fasure KA (2005) Screening of crude extracts of six medicinal plants used in South-West Nigerian unorthodox medicine for anti-methicillin resistant Staphylococcus aureus activity. BMC Complementary and Alternative Medicine 5 (6). DOI: 10.1186/1472-6882-5-6
Al-Bayati M, Issa R, Abu-Samak M, Alnsour L, Awwad S (2023) Phytochemical analysis and evaluation of anti-hyperlipidaemic effect for ethanolic leaf extract of Equisetum ramosissimum L.: in vivo study on rats’ models. Pharmacia 70(3): 557-568. Doi: 10.3897/pharmacia.70.e101623
Alsharedeh RH, Alshraiedeh NH, Masadeh MM, Alzoubi KH, Al-Fandi MG, Hayajneh RH, Atawneh FH, Shubair ZA (2023) Biofilm formation by E. coli and S. aureus on cellphone cover: sensitivity to commercially available sanitizers. Pharmacia 70(1): 181-186. https://doi.org/10.3897/pharmacia.70.e95865
Amoabeng BW, Gurr GM, Gitau CW, Nicol HI, Munyakazi L, Stevenson PC (2013) Tri-trophic insecticidal effects of African plants against cabbage pests. PLoS One 8(10): e78651. 10.1371/journal.pone.0078651
Antai AB, Eyong EU, Eteng MU, Itam EH, Eko ME, Ita SO (2009) Serum protein and enzyme levels in rats following administration of ethanolic leaf extract of Ageratum conyzoides (goat weed). Nigerian Journal of Physiological Sciences 24(2): 117-20. DOI: 10.4314/njps.v24i2.52900
Arulprakash K, Murugan R, Ponrasu T, Iyappan K, Gayathri VS, Suguna L (2012) Efficacy of Ageratum conyzoides on tissue repair and collagen formation in rats. Clinical and Experimental Dermatology 37(4): 418-24. DOI: 10.1111/j.1365-2230.2011.04285.x
Atawodi SE, Adepoju OA, Nzelibe HC (2017) Antihyperglycaemic and hypolipidemic effect of methanol extracts of Ageratum conyzoides L (Asteraceae) in normal and diabetic rats. African Journal Online 16(5): 989-96. DOI: 10.4314/tjpr.v16i5.4
Atisha SA, Mita SR (2018) Review: Herban Bandotan (Ageratum conyzoides L.) Sebagai Pengobatan Luka Terbuka. Farmaka 16(3): 116-21. DOI: 10.24198/jf.v16i3.17419
Bahtiar A, Nurazizah M, Roselina T, Tambunan AP, Arsianti A (2017) Ethanolic extracts of babandotan leaves (Ageratum conyzoides L.) prevents inflammation and proteoglycan degradation by inhibiting TNF-α and MMP-9 on osteoarthritis rats induced by monosodium iodoacetate. Asian Pacific Journal of Tropical Medicines 10(3): 270-7. DOI: 10.1016/j.apjtm.2017.03.006
Bamidele O, Akinnuga AM, Anyakudo MMC, Ojo OA, Ojo GB, Olorunfemi JO, Johnson OP (2010) Haemostatic effect of methanolic leaf extract of Ageratum conyzoides in albino rats. Journal of Medicinal Plants Research 4(20): 2075-9. https://academicjournals.org/journal/JMPR/article-full-text-pdf/41402DF16208#:~:text=plasma%20fibrinogen%20concentration.-,The%20methanolic%20leaf%20extract%20of%20A.,by%20increasing%20plasma%20fibrinogen%20concentration.
Bouda H, Tapondjou LA, Fontem DA, Gumedzoe MY (2001) Effect of essential oils from leaves of Ageratum conyzoides, Lantana camara and Chromolaena odorata on the mortality of Sitophilus zeamais (Coleoptera, Curculionidae). Journal of Stored Product Research 37(2): 103-9. DOI: 10.1016/s0022-474x(00)00011-4
Cáceres A, Menéndez H, Méndez E, Cohobón E, Samayoa BE, Jauregui E, Peralta E, Carrillo G (1995) Antigonorrhoeal activity of plants used in Guatemala for the treatment of sexually transmitted diseases. Journal of Ethnopharmacology 48(2): 85-8. DOI: 10.1016/0378-8741(95)01288-o
Chah KF, Eze CA, Emuelosi CE, Esimone CO (2006) Antibacterial and wound healing properties of methanolic extracts of some Nigerian medicinal plants. Journal of Ethnopharmacology 104(1-2): 164-7. DOI: 10.1016/j.jep.2005.08.070
Chude CF, Okorie CJ, Ayegbunam ES, Aghalu UC (2020) Larvicidal Activity of Leaf Extracts of Ageratum conyzoides and Hyptis Suaveolens Against Aedes aegypti. International Journal of Engineering Applied Science and Technology 4(10): 304-9. DOI: 10.33564/IJEAST.2020.v04i10.056
De Mello SVGV, da Rosa JS, Facchin BM, Luz AB, Vicente G, Faqueti LG, Rosa DW, Biavatti MW, Fröde TS (2016) Beneficial effect of Ageratum conyzoides Linn (Asteraceae) upon inflammatory response induced by carrageenan into the mice pleural cavity. Journal of Ethnopharmacology 194: 337-47. DOI: 10.1016/j.jep.2016.09.003
De Melo NI, Magalhaes LG, de Carvalho CE (2011) Schistosomicidal activity of the essential oil of Ageratum conyzoides L. (Asteraceae) against adult Schistosoma mansoni worms. Molecules 16(1): 762-73. DOI: 10.3390/molecules16010762
De Mendonça FA, da Silva KF, dos Santos KK, Ribeiro Júnior KA, Sant'Ana AE (2005) Activities of some Brazilian plants against larvae of the mosquito Aedes aegypti. Fitoterapia 76(7-8): 629-36. DOI: 10.1016/j.fitote.2005.06.013
Detering M, Steels E, Koyyalamudi SR, Allifranchini E, Bocchietto E, Vitetta L (2017) Ageratum conyzoides L. inhibits 5-alpha-reductase gene expression in human prostate cells and reduces symptoms of benign prostatic hypertrophy in otherwise healthy men in a double blind randomized placebo controlled clinical study. Biofactors 43(6): 789-800. DOI: 10.1002/biof.1389
Dewan SMR, Amin MR, Adnan T, Uddin SMN, Shahid-Ud-Daula AFM, Sarwar G, Hossain MdS (2013) Investigation of analgesic potential and in vitro antioxidant activity of two plants of Asteraceae family growing in Bangladesh. Journal of Pharmacy Research 6(6): 599-603. DOI: 10.1016/j.jopr.2013.05.016
Diallo A, Eklu-Gadegbeku K, Agbono A, Aklikokou K, Creppy EE, Gbeassor M (2010) Acute and Sub-chronic (28-day) Oral Toxicity Studies of Hydroalcohol Leaf Extract of Ageratum conyzoides L (Asteraceae). African Journal Online 9(5): 463-7. 10.4314/tjpr.v9i5.61059
Diallo A, Eklu-Gadegbeku K, Amegbor K, Agbonon A, Aklikokou K, Creppy E, Gbeassor M (2014) In vivo and in vitro toxicological evaluation of the hydroalcoholic leaf extract of Ageratum conyzoides L. (Asteraceae). Journal of Ethnopharmacology 155(2): 1214-8. DOI: 10.1016/j.jep.2014.07.005
do Rosário CJRM, da Rocha CQ, de Aguiar DM, Lima CAA, Silveira DPB, Leite, J. A. C., Coutinho, D. F., & Melo, F. A. (2019) Anti-Ehrlichia properties of the essential oil of Ageratum conyzoides L. and its interaction with doxycycline. AMB Express, 9(1), 58. DOI: 10.1186/s13568-019-0780-y
Durodola JI (1977) Antibacterial property of crude extracts from a herbal wound healing remedy-Ageratum conyzoides, L. Planta Medica 32(4): 388-90. 10.1055/s-0028-1097620
Esper RH, Gonçalez E, Marques MO, Felicio RC, Felicio JD (2014) Potential of essential oils for protection of grains contaminated by aflatoxin produced by Aspergillus flavus. Frontiers in Microbiology 5: 269. DOI: 10.3389/fmicb.2014.00269
Fadehan DG, Boamah D, Adotei Edoh D, Lartey O, Addo-Appenteng M (2015) Screening of Ageratum conyzoides Linn. and Alchornea cordifolia (Schumach. & Thonn.) Extracts for Antibacterial Activity. European Journal of Medicinal Plants 10(4): 1-7. DOI: 10.9734/EJMP/2015/20739.
Fraqueti LG, Brieudes V, Halabalaki M, Skaltsounis AL, Nascimento LF, Barros WM, Santos AR, Biavatti MW (2016) Antinociceptive and anti-inflammatory activities of standardized extract of polymethoxyflavones from Ageratum conyzoides. Journal of Ethnopharmacology 194: 369-77. DOI: 10.1016/j.jep.2016.09.025.
Garcia EA, Carvalho MP (1999) Electrophysiological effects of Ageratum conyzoides L. on the guinea-pig heart. Phytotherapy Research 13(2): 172-4. DOI: 10.1002/(SICI)1099-1573(199903)13:2<172::AID-PTR394>3.0.CO;2-Z.
Habibie A, Raharjo TJ, Swasono RT, Retnaningrum E (2023) Antibacterial activity of active peptide from marine macroalgae Chondrus crispus protein hydrolysate against Staphylococcus aureus. Pharmacia 70(4): 983-992. DOI: 10.3897/pharmacia.70.e112215
Harel D, Khalid SA, Kaiser M, Brun R, Wünsch B, Schmidt TJ (2011) Encecalol angelate, an unstable chromene from Ageratum conyzoides L.: total synthesis and investigation of its antiprotozoal activity. Journal of Ethnopharmacology 137(1): 620-5. DOI: 10.1016/j.jep.2011.06.015
Hariono M, Rollando R, Karamoy J, Hariyono P, Atmono M, Djohan M, Wiwy W, Nuwarda R, Kurniawan C, Salin N, Wahab H (2020) Bioguided Fractionation of Local Plants against Matrix Metalloproteinase 9 and Its Cytotoxicity against Breast Cancer Cell Models: In Silico and In Vitro Study. Molecules 25(20): 4691. DOI: 10.3390/molecules26051464
Hossain H, Karmakar UK, Biswas SK, Shahid-Ud-Daula AF, Jahan IA, Adnan T, Chowdhury A (2013) Antinociceptive and antioxidant potential of the crude ethanol extract of the leaves of Ageratum conyzoides grown in Bangladesh. Pharmaceutical Biology 51(7): 893-8. doi: 10.3109/13880209.2013.770535. DOI: 10.3109/13880209.2013.770535
Hu F, Kong C, Xu X, Zhou B (2002) Inhibitory effect of flavones from Ageratum conyzoides on the major pathogens in citrus orchard. Ying Yong Sheng Tai Xue Bao 13(9): 1166-8. https://pubmed.ncbi.nlm.nih.gov/12561185/
Ingrid DT, Akwanjoh SR, Manjeli (2020) Histopathological effects of Ageratum conyzoides (Asteraceae) on the male reproductive system of the pest grasshopper Zonocerus variegatus (Orthoptera: Pyrgomorphidae). Journal of Entomology and Zoology Studies 8: 643-7. https://www.entomoljournal.com/archives/2020/vol8issue5/PartI/8-4-409-796.pdf
Ingrid DT, Akwanjoh SR, Yacouba M (2020) Insecticidal Activity of Ageratum conyzoides (Asteraceae) Aqueous Extracts against the Grasshopper Zonocerus variegatus (Orthoptera: Pyrgomorphidae). Journal of Agriculture and Ecology Research International 21(8): 29-36. DOI: 10.9734/jaeri/2020/v21i830159
Ita SO, Etim OE, Ben EE, Ekpo OF (2007) Haematopoietic properties of ethanolic extract of Ageratum conyzoides (goat weed) in albino rats. Nigerian Journal of Physiological Sciences 22(1-2): 83-7. DOI: 10.4314/njps.v22i1-2.54883
Jagetia GC, Shirwaikar A, Rao SK, Bhilegaonkar PM (2003) Evaluation of the radioprotective effect of Ageratum conyzoides Linn. extract in mice exposed to different doses of gamma radiation. Journal of Pharmacy and Pharmacology 55(8): 1151-8. DOI: 10.1211/0022357021576
Jaya, Singh P, Prakash B, Dubey NK (2014) Insecticidal activity of Ageratum conyzoides L., Coleus aromaticus Benth. and Hyptis suaveolens (L.) Poit essential oils as fumigant against storage grain insect Tribolium castaneum Herbst. Journal of Food Science and Technology 51(9): 2210-5. DOI: 10.1007/s13197-012-0698-8
Kalinkova M, Kadiyska T, Handjieva-Darlenska T (2023) Pharmacogenetics of Glucagon-like-peptide-1 receptor in diabetes management. Pharmacia 70(2): 383-390. DOI: 10.3897/pharmacia.70.e104481
Kamboj A, Saluja AK (2008) Ageratum conyzoides L.: A review on its Phytochemical and Pharmacological Profile. International Journal of Green Pharmacy 2(2): 59-68. DOI: 10.4103/0973-8258.41171
Kaou AM, Mahiou-Leddet V, Hutter S, Aïnouddine S, Hassani S, Yahaya I, Azas N, Ollivier E (2008) Antimalarial activity of crude extracts from nine African medicinal plants. Journal of Ethnopharmacology 116(1): 74-83. DOI: 10.1016/j.jep.2007.11.001
Karimi A, Majlesi M, Rafieian-Kopaei M (2015) Herbal versus synthetic drugs; beliefs and facts. Journal of Nephropharmacology 4(1): 27-30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297475/
Kumar KGA, Fular A, Chigure G, Sharma AK, Nagar G, Souza FF, Bechara GH, Ghosh S (2019) Comparative impact of coumaphos, amitraz and plant extract of Ageratum conyzoides on the oogenesis of Rhipicephalus microplus. Ticks Tick Borne Diseases 10(5): 1085-95. DOI: 10.1016/j.ttbdis.2019.06.003
Kumar KGA, Tayade AB, Kumar R, Gupta S, Sharma AK, Nagar G, Tewari SS, Kumar B, Rawat AK, Srivastava S, Kumar S, Ghosh S (2016) Chemo-profiling and bioassay of phytoextracts from Ageratum conyzoides for acaricidal properties against Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) infesting cattle and buffaloes in India. Ticks Tick Borne Diseases 7(2): 342-349. 10.1016/j.ttbdis.2015.12.005
Lin Z, Lin Y, Shen J, Jiang M, Hou Y (2020) Flavonoids in Ageratum conyzoides L. Exert Potent Antitumor Effects on Human Cervical Adenocarcinoma HeLa Cells In Vitro and In Vivo. Biomed Research International 2020: 2696350. DOI: 10.1155/2020/2696350
Losica RKS, Valte V, Sailo ZA (2019) A study of the analgesic effect of aqueous extract of the whole plant of Ageratum conyzoides Linn. in experiments on animal models. International Journal of Pharmacy Practice 6(1): 28-32. 10.18231/2393-9087.2019.0007
Madureira DCDM, Paula-Martins A, Gomes M, Paiva J, Proença da Cunha A, do Rosário V (2002) Antimalarial activity of medicinal plants used in traditional medicine in S. Tomé and Príncipe islands. Journal of Ethnopharmacology 81(1): 23-9. doi: 10.1016/s0378-8741(02)00005-3. DOI: 10.1016/s0378-8741(02)00005-3
Mohammed YH, Hassan AF (2023) Evaluation the anti-inflammatory effect of Omega 369 against acetaminophen-induced hepatotoxicity in mice. Pharmacia 70(3): 419-424. DOI: 10.3897/pharmacia.70.e103711
Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Medicine 6(7): e1000097. DOI: 10.1136/bmj.b2535
Moody JO, Adebiyi OA, Adeniyi BA (2004) Do Aloe vera and Ageratum conyzoides enhance the anti-microbial activity of traditional medicinal soft soaps (Osedudu)? Journal of Ethnopharmacology 92(1): 57-60. DOI: 10.1016/j.jep.2004.01.018
Moreira MD, Picanço MC, Barbosa LC, Guedes RN, Barros EC, Campos MR (2007) Compounds from Ageratum conyzoides: isolation, structural elucidation and insecticidal activity. Pest Management Science 63(6): 615-21. DOI: 10.1002/ps.1376
Moura AC, Silva EL, Fraga MC, Wanderley AG, Afiatpour P, Maia MB (2005) Antiinflammatory and chronic toxicity study of the leaves of Ageratum conyzoides L. in rats. Phytomedicine 12(1-2): 138-142. DOI: 10.1016/j.phymed.2003.12.003
Nasrin F (2013) Antioxidant and cytotoxic activities of Ageratum conyzoides stems. International Current Pharmaceutical Journal 2(2): 33-7. DOI: 10.3329/icpj.v2i2.13195
Ndip RN, Malange-Tarkang AE, Mbullah SM, Luma HN, Malongue A, Ndip LM, Nyongbela K, Wirmum C, Efange SM (2007) In vitro anti-Helicobacter pylori activity of extracts of selected medicinal plants from North West Cameroon. Journal of Ethnopharmacology 114(3) 452-7. DOI: 10.1016/j.jep.2007.08.037
Ngnameko CR, Njayou FN, Fowora M, Nemg FBS, Fewou PM, Smith SI (2019) Inhibitory effect of medicinal plants from Cameroon on the growth and adhesion of Helicobacter pylori. European Journal of Integrative Medicine (30): 100957. DOI: 10.1016/j.eujim.2019.100957
Nogueira JH, Gonçalez E, Galleti SR, Facanali R, Marques MO, Felício JD (2010) Ageratum conyzoides essential oil as aflatoxin suppressor of Aspergillus flavus. International Journal of Food Microbiology 137(1): 55-60. DOI: 10.1016/j.ijfoodmicro.2009.10.017
Nour AMM, Khalid SA, Kaiser M, Brun R, Abdalla WE, Schmidt TJ (2010) The antiprotozoal activity of methylated flavonoids from Ageratum conyzoides L. Journal of Ethnopharmacology 129(1): 127-130. DOI: 10.1016/j.jep.2010.02.015
Nweze NE, Obiwulu IS (2009) Anticoccidial effects of Ageratum conyzoides. Journal of Ethnopharmacology 122(1): 6-9. DOI: 10.1016/j.jep.2008.11.014
Nyunaï M, Dicoum AM, Njifutié N, Abdennebi EH, Gérard C (2010) Antihyperglycaemic effect of Ageratum conyzoides L. fractions in normoglycemic and diabetic male wistar rats. International Journal of Pharmacy and Biological Sciences 2010 4 (1): 38-42. http://www.globalsciencebooks.info/Online/GSBOnline/images/2010/IJBPS_4(1&2)/IJBPS_4(1)38-42o.pdf
Nyunaï N, Njikam N, Abdennebi el H, Mbafor JT, Lamnaouer D (2009) Hypoglycaemic and antihyperglycaemic activity of Ageratum conyzoides L. in rats. African Journal of Traditional, Complementary and Alternative Medicines 6(2): 123-30. DOI: 10.4314/ajtcam.v6i2.57083
Ogbole OO, Akinleye TE, Segun PA, Faleye TC, Adeniji AJ (2018). In vitro antiviral activity of twenty-seven medicinal plant extracts from Southwest Nigeria against three serotypes of echoviruses. Virology Journal 15(1): 110. DOI: 10.1186/s12985-018-1022-7
Ogunlade B, Yama OE, Saalu LC, Clement AB (2013) Ageratum conyzoides attenuates alcohol induced liver toxicity in male Wistar rats. Nigerian Quarterly Journal of Hospital Medicine 23(1): 48-53. https://pubmed.ncbi.nlm.nih.gov/24579495/
Ojewale A, Mada S, Oyebadejo S, Afodun A, Aladeyelu O, Kolawole B (2020) Cardioprotective Activities of Ethanolic Extract Root of Ageratum conyzoides on Alloxan-Induced Cardiotoxicity in Diabetic Rats. Biomed Research International 2020: 3189672. DOI: 10.1155/2020/3189672
Ola-Davies OE, Akinrinde AS (2016) Acute Sodium Arsenite-Induced Hematological and Biochemical Changes in Wistar Rats: Protective Effects of Ethanol Extract of Ageratum conyzoides. Pharmacognosy Research 8(Suppl 1): S26-30. DOI: 10.4103/0974-8490.178645
Oladejo OW, Imosemi IO, Osuagwu FC, Oyedele OO, Oluwadara OO, Ekpo OE, Aiku A, Adewoyin O, Akang EE (2003) A comparative study of the wound healing properties of honey and Ageratum conyzoides. African Journal of Medicines and Medical Sciences 32(2): 193-6. https://pubmed.ncbi.nlm.nih.gov/15032468/
Olajide OA (1999) Investigation of the effects of selected medicinal plants on experimental thrombosis. Phytotherapy Research 13(3): 231-2. DOI: 10.1002/(SICI)1099-1573(199905)13:3<231::AID-PTR414>3.0.CO;2-2
Owuor BO, Ochanda JO, Kokwaro JO, Cheruiyot AC, Yeda RA, Okudo CA, Akala HM (2012) In vitro antiplasmodial activity of selected Luo and Kuria medicinal plants. Journal of Ethnopharmacology 144(3): 779-81. DOI: 10.1016/j.jep.2012.09.045
Palmer PA, Jessica A, Bryson, Amy E (2019) A comprehensive toxicological safety assessment of an extract of Ageratum conyzoides. Regulatory Toxicology and Pharmacology 103: 140-9. DOI: 10.1016/j.yrtph.2019.01.027
Panda SK, Mohanta YK, Padhi L, Park YH, Mohanta TK, Bae H Erratum: Panda SK (2016) Large-Scale Screening of Ethnomedicinal Plants for Identification of Potential Antibacterial Compounds. Molecules 21: 293. DOI: 10.3390/molecules21030293
Parlar Köprülü RE (2023) How to create an experimental diabetes mellitus model? Pharmacia 70(1): 105-111. https://doi.org/10.3897/pharmacia.70.e96028
Parveen S, Godara R, Katoch R, Yadav A, Verma PK, Katoch M, Singh NK (2014) In vitro evaluation of ethanolic extracts of Ageratum conyzoides and Artemisia absinthium against cattle tick, Rhipicephalus microplus. Scientific World Journal 2014: 858973. DOI: 10.1155/2014/858973
Patil RP, Nimbalkar MS, Jadhav UU, Dawkar VV, Govindwar SP (2010) Antiaflatoxigenic and antioxidant activity of an essential oil from Ageratum conyzoides L. Journal of the Science of Food and Agriculture 90(4): 608-14. DOI: 10.1002/jsfa.3857
Pelkonen O, Xu Q, Fan TP (2014) Why is Research on Herbal Medicinal Products Important and How Can We Improve Its Quality? Journal of Traditional and Complementary Medicine 4(1): 1-7. DOI: 10.4103/2225-4110.124323
Perumal-Samy R, Ignacimuthu S, Raja DP (1999) Preliminary screening of ethnomedicinal plants from India. Journal of Ethnopharmacology 66(2): 235-40. DOI: 10.1016/s0378-8741(99)00038-0
Petrovska BB (2012) Historical review of medicinal plants' usage. Pharmacognosy Review 6(11): 1-5. DOI: 10.4103/0973-7847.95849
Pintong AR, Ampawong S, Komalamisra N, Sriwichai P, Popruk S, Ruangsittichai J (2020) Insecticidal and Histopathological Effects of Ageratum conyzoides Weed Extracts against Dengue Vector, Aedes aegypti. Insects 11(4): 224. DOI: 10.3390/insects11040224
Pintong AR, Ruangsittichai J, Ampawong S, Thima K, Sriwichai P, Komalamisra N, Popruk S (2020) Efficacy of Ageratum conyzoides extracts against Giardia duodenalis trophozoites: an experimental study. BMC Complementary Medicines and Therapy 20(1): 63. DOI: 10.1186/s12906-020-2860-6
Poné WJ, Fossi Tankoua O, Yondo J, Komtangi MC, Mbida M, Bilong Bilong CF (2011) The In Vitro Effects of Aqueous and Ethanolic Extracts of the Leaves of Ageratum conyzoides (Asteraceae) on Three Life Cycle Stages of the Parasitic Nematode Heligmosomoides bakeri (Nematoda: Heligmosomatidae). Veterinary Medicine International 2011: 140293. DOI: 10.4061/2011/140293
Prima SR, Elfahmi, Julianti E, Fidrianny I (2023) Update review: Etnopharmacological, bioactivity and phytochemical of Allium cepa L. Pharmacia 70(3): 717-724. DOI: 10.3897/pharmacia.70.e99666
Qnais E, Alqudah A, Wedyan M, Athamneh RY, Bseiso Y, Abudalo R, Oqal M, Gammoh O (2023) Potential anti-inflammatory activity of the Tamarix aphylla essential oil. Pharmacia 70(3): 707-715.DOI: 10.3897/pharmacia.70.e107237
Quoc LPT (2020) Physicochemical Properties and Antibacterial Activity of Essential Oil of Ageratum conyzoides L. Leaves. Agriculturae Conspectus Scientificus 85(2): 139-144. DOI: 10.4314/bcse.v35i3.18
Rahman MA, Sultana R, Bin-Emran T, Islam MS, Rahman MA, Chakma JS, Rashid HU, Hasan CM (2013) Effects of organic extracts of six Bangladeshi plants on in vitro thrombolysis and cytotoxicity. BMC Complementary and Alternative Medicine 13: 25. DOI: 10.1186/1472-6882-13-25
Randrianavony P, Quansah N, Djoudi R, Quansah NA, Randimbivololona F (2020) Anticonvulsant Activity of Hydroalcoholic Extract of Ageratum conyzoides L. (Asteraceae) in Mice. European Scientific Journal, 16(18): 114. DOI: 10.19044/esj.2020.v16n18p114
Razafindrakoto ZR, Tombozara N, Ramanitrahasimbola D, Raoelihajaina DF, Rakotondramanana, DA (2020) Vasorelaxing activity of Ageratum conyzoides Linn. (Asteraceae) aerial parts on isolated rat aorta. 2020. American Journal of Innovative Research & Applied Sciences 10(4): 165-171. https://american-jiras.com/Zoarilala-Ref.1-ajira310320.pdf
Rosangkima G, Prasad SB (2004) Antitumour activity of some plants from Meghalaya and Mizoram against murine ascites Dalton's lymphoma. Indian Journal of Experimental Biology 42(10): 981-8. https://pubmed.ncbi.nlm.nih.gov/15511001/
Saputri MP (2020) Anti-inflammation Activity of Ageratum conyzoides Leaf Ethanol Extract on Rattus Norvegicus. Walisongo Journal of Chemistry 3(1): 46-51. DOI: 10.21580/wjc.v3i1.6136
Sarfo-Antwi F, Larbie C, Babatunde D (2019) Extracts of Ageratum conyzoides L. Protects against Carbon Tetrachloride – Induced Toxicity in Rats through Inhibiting Oxidative Stress. Journal of Advances in Medical and Pharmaceutical Sciences 19(2): 1-14. DOI: 10.3390/molecules24101964
Shailajan S, Wadke P, Joshi H, Tiwari B (2013) Evaluation of quality and efficacy of an ethnomedicinal plant Ageratum conyzoides L. in the management of pediculosis. Journal of Young Pharmacists 5(4): 139-43. DOI: 10.1016/j.jyp.2013.10.005
Sharma P, Mohan L, Srivastava CN (2009) Anti-juvenile activity of Azadirachta indica extract on the development and morphometry of filaria vector, Culex quinquefasciatus (Diptera: Culicidae) Say. Parasitology Research 105(5): 1193-203. DOI: 10.1007/s00436-009-1537-3
Shirwaikar A, Bhilegaonkar PM, Malini S, Kumar JS (2003) The gastroprotective activity of the ethanol extract of Ageratum conyzoides. Journal of Ethnopharmacol 86(1): 117-121. DOI: 10.1016/s0378-8741(03)00050-3
Silva MJ, Capaz FR, Vale MR (2000) Effects of the water soluble fraction from leaves of Ageratum conyzoides on smooth muscle. Phytotherapy Research 14(2): 130-2. DOI: 10.1002/(sici)1099-1573(200003)14:2<130::aid-ptr594>3.0.co;2-4
Singh BR, Singh V, Ebibeni N, Singh RK (2013) Antimicrobial and Herbal Drug Resistance in Enteric Bacteria Isolated from Faecal Droppings of Common House Lizard/Gecko (Hemidactylus frenatus). Interantional Journal of Microbiology 2013: 340848. DOI: 10.1155/2013/340848
Soares SF, Borges LM, de Sousa Braga R, Ferreira LL, Louly CC, Tresvenzol LM, de Paula JR, Ferri PH (2010) Repellent activity of plant-derived compounds against Amblyomma cajennense (Acari: Ixodidae) nymphs. Veterinary Parasitology 167(1): 67-73. DOI: 10.1016/j.vetpar.2009.09.047
Stambolov I, Shkondrov A, Krasteva I (2023) Astragalus glycyphyllos L.: Phytochemical constituents, pharmacology, and biotechnology. Pharmacia 70(3): 635-641. DOI: 10.3897/pharmacia.70.e107989
Subah S, Bogoda N, Glávits R, Venkatesh R, Murbach TS, Kolep-Csete K (2020) Prenatal developmental toxicity study of an alkaloid-free Ageratum conyzoides extract powder in rats by oral administration. Regulatory Toxicology and Pharmacology 117: 104748. DOI: 10.1016/j.yrtph.2020.104748
Sukmawan YP, Suhendy H (2017) Haemostatic effect of ethanolic extract of Ageratum conyzoides L. to strains of mice male swiss webster induced with combination of aspirin, clopidogrel and Enoxaparin. Asian Journal of Pharmaceutical and Clinical Research 10(7): 276-9. DOI: 10.22159/ajpcr.2017.v10i7.18573
Sukmawan YP, Anggadiredja K, Adnyana IK (2021) Anti-Neuropathic Pain Activity of Ageratum conyzoides L due to The Essential Oil Components. CNS and Neurological Disorders Drug Targets 20(2): 181-9. DOI: 10.2174/1871527319666201120144228
Swandiny GF, Primahana G, Prastya ME, Ariani N, Susanti D, Hanafi M, Abdillah S (2023) An ethnopharmacology study of Indonesian medicinal plants in Gunung Sari village as dipeptidyl peptidase-IV inhibitor. Pharmacia 70(2): 365-373. DOI: 10.3897/pharmacia.70.e104437
Teixeira TL, Teixeira SC, da Silva C V, de Souza MA (2014) Potential therapeutic use of herbal extracts in trypanosomiasis. Pathogens and Global Health 108(1): 30-6. DOI: 10.1179/2047773213Y.0000000120
Trinh PC, Thao LT, Ha HT, Nguyen T (2020) DPPH-Scavenging and Antimicrobial Activities of Asteraceae Medicinal Plants on Uropathogenic Bacteria. Evidence-Based Complementary and Alternative Medicine 2020: 7807026. DOI: 10.1155/2020/7807026
Verma PK, Raina R, Sultana M, Prawez S, Jamwal N (2013) Hepatoprotective mechanisms of Ageratum conyzoides L. on oxidative damage induced by acetaminophen in Wistar rats. Free Radicals and Antioxidant 3: 73–6. DOI: 10.1016/j.fra.2013.05.009
Vickers A, Zollman C, Lee R (2001) Herbal medicine. The Western Journal of Medicine 175(2): 125-8. DOI: 10.1136/ewjm.175.2.125
Voukeng IK, Beng VP, Kuete V (2016) Antibacterial activity of six medicinal Cameroonian plants against Gram-positive and Gram-negative multidrug resistant phenotypes. BMC Complementary and Alternative Medicine 16(1): 388. DOI: 10.1186/s12906-016-1371-y
Yamamoto LA, Soldera JC, Emim JA, Godinho RO, Souccar C, Lapa AJ (1991) Pharmacological screening of Ageratum conyzoides L. (Mentrasto). Mem Inst Oswaldo Cruz, 86 (Suppl 2), 145-147. DOI: 10.1590/s0074-02761991000600033
Yuan H, Ma Q, Ye L, Piao G (2016) Traditional Medicine and Modern Medicine from Natural Products. Molecules 21(5): 559. DOI: 10.3390/molecules21050559
Zhang AL, Changli Xue C, Fong HHS (2011) Integration of Herbal Medicine into Evidence-Based Clinical Practice: Current Status and Issues. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 22. Available online from: https://www.ncbi.nlm.nih.gov/books/NBK92760/. [Accessed October, 2022].
Zhang G, Li J, Sun Q, Zhang K, Xu W, Zhang Y, Wu G (2021) Pathological Features of Echovirus-11-Associated Brain Damage in Mice Based on RNA-Seq Analysis. Viruses 13(12): 2477. DOI: 10.3390/v13122477.
