PENGARUH SONIKATOR PROBE TERHADAP FORMULASI NANOSTRUCTURED LIPID CARRIERS KURKUMIN MENGGUNAKAN LIPID PADAT PRECIROL®

EFFECT OF PROBE SONICATOR ON CURCUMIN NANOSTRUCTURED LIPID CARRIERS USING PRECIROL® SOLID LIPIDS

Authors

  • Garnadi Jafar Bhakti Kencana University, Indonesia
  • Silpi Pebriawati Fakultas Farmasi, Universitas Bhakti Kencana
  • Zahra Alfa Latifah Fakultas Farmasi, Universitas Bhakti Kencana, Indonesia
  • Reza Pratama Fakultas Farmasi, Universitas Bhakti Kencana, Indonesia

DOI:

https://doi.org/10.36465/jkbth.v25i1.1451

Keywords:

Nanostructured Lipid Carriers, Kurkumin, AGA

Abstract

Androgenetic Alopecia (AGA) merupakan jenis kebotakan yang sering terjadi pada pria dan wanita yang dipengaruhi oleh hormon dihidrotestosteron (DHT). Minoksidil dan finasterid merupakan terapi umum untuk pengobatan AGA. Namun, minoksidil dan finasterid dapat menyebabkan efek samping dermatologis seperti iritasi kulit, ruam, dan dermatitis kontak alergi maka diperlukan pengobatan alternatif untuk mengurangi efek samping yang ditimbulkan. Kurkumin dipilih karena efek antiandrogeniknya yang dapat menghambat steroid 5-alpha reductase sehingga dapat menurunkan hormon DHT yang berlebih dalam tubuh. Namun, kurkumin ini memiliki banyak keterbatasan diantaranya sukar larut dalam air, bioavailabilitas yang rendah, log P 2,56-3,29 dan mudah terdegradasi sehingga efektivitas pengobatan tidak optimal. Oleh sebab itu, diperlukan suatu sistem penghantaran obat yang tepat seperti Nanostructured Lipid Carriers (NLC) sehingga dapat meningkatkan efektivitas biologisnya. NLC merupakan generasi kedua nanocarrier lipid yang memiliki keunggulan dalam meningkatkan solubilitas, stabilitas, dan kapasitas pemuatan obat dibandingkan dengan Solid Lipid Nanoparticle (SLN). Tujuan penelitian ini yaitu untuk memformulasikan NLC kurkumin menggunakan Glyceryl palmitostearate, Capric triglyceride dengan 2 jenis surfaktan yang berbeda yaitu PEG-40 hydrogenated castor oil dan Decyl Glucoside. Metode penelitian yang digunakan untuk pembuatan NLC kurkumin ini yaitu high shear homogenization/sonicator probe yang dapat menghasilkan gelombang suara yang tinggi menyebabkan kavitasi sehingga ukuran partikel menjadi lebih kecil dan menciptakan gerakan turbulen yang dapat mempercepat proses pencampuran. Hasil penelitian menunjukkan bahwa NLC kurkumin dengan menggunakan surfaktan PEG-40 hydrogenated castor oil dan Decyl Glucoside memiliki karakteristik yang sesuai dengan ukuran partikel <400 nm, potensial zeta > ±20 mV, efisiensi penjerapan >80%, dan morfologi sferis. Dengan demikian, diharapkan NLC kurkumin dapat meningkatkan stabilitas dan bioavailabilitas kurkumin untuk memaksimalkan efektivitas pengobatan AGA.

References

Bang, K.-H., Na, Y.-G., Huh, H. W., Hwang, S.-J., Kim, M.-S., Kim, M., Lee, H.-K., & Cho, C.-W. (2019). The Delivery Strategy of Paclitaxel Nanostructured Lipid Carrier Coated with Platelet Membrane. Cancers, 11(6), 807. https://doi.org/10.3390/cancers11060807

Bhattacharjee, S. (2016). DLS and zeta potential - What they are and what they are not? Journal of Controlled Release, 235, 337–351. https://doi.org/10.1016/j.jconrel.2016.06.017

Brito Raj, S., Chandrasekhar, K. B., & Reddy, K. B. (2019). Formulation, in-vitro and in-vivo pharmacokinetic evaluation of simvastatin nanostructured lipid carrier loaded transdermal drug delivery system. Future Journal of Pharmaceutical Sciences, 5(1). https://doi.org/10.1186/s43094-019-0008-7

Caon, T., Mazzarino, L., Simões, C. M. O., Senna, E. L., & Silva, M. A. S. (2017). Lipid- and Polymer-Based Nanostructures for Cutaneous Delivery of Curcumin. AAPS PharmSciTech, 18(3), 920–925. https://doi.org/10.1208/s12249-016-0554-7

Del Prado-Audelo, M. L., Caballero-Florán, I. H., Meza-Toledo, J. A., Mendoza-Muñoz, N., González-Torres, M., Florán, B., Cortés, H., & Leyva-Gómez, G. (2019). Formulations of curcumin nanoparticles for brain diseases. Biomolecules, 9(2), 1–28. https://doi.org/10.3390/biom9020056

Fathi, H. A., Allam, A., Elsabahy, M., Fetih, G., & El-Badry, M. (2018). Nanostructured lipid

carriers for improved oral delivery and prolonged antihyperlipidemic effect of simvastatin. Colloids and Surfaces B: Biointerfaces, 162, 236–245. https://doi.org/10.1016/j.colsurfb.2017.11.064

Gupta, V., & Trivedi, P. (2018). In vitro and in vivo characterization of pharmaceutical topical nanocarriers containing anticancer drugs for skin cancer treatment. In Lipid Nanocarriers for Drug Targeting. Elsevier Inc. https://doi.org/10.1016/B978-0-12-813687-4.00015-3

Hosking, A. M., Juhasz, M., & Atanaskova Mesinkovska, N. (2019). Complementary and Alternative Treatments for Alopecia: A Comprehensive Review. In Skin Appendage Disorders (Vol. 5, Issue 2, pp. 72–89). S. Karger AG. https://doi.org/10.1159/000492035

Ide, H., Lu, Y., Noguchi, T., Muto, S., Okada, H., Kawato, S., & Horie, S. (2018). Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer. Cancer Science, 109(4), 1230–1238. https://doi.org/10.1111/cas.13517

Jafar, G., Salsabilla, S., & Santoso, R. (2022). DEVELOPMENT AND CHARACTERIZATION OF COMPRITOL ATO® BASE IN NANOSTRUCTURED LIPID CARRIERS FORMULATION WITH THE PROBE SONICATION METHOD. International Journal of Applied Pharmaceutics, 14(Special Issue 4), 64–66.https://doi.org/10.22159/ijap.2022.v14s4.PP04

Japar Sodik, J., Dinata, D. I., Kusriani, R. H., & Jafar, G. (2023). Comparison of Analysis Methods for Curcumin Determination: a Literature Review. Medical Sains : Jurnal Ilmiah Kefarmasian, 8(4), 1489–1502. https://doi.org/10.37874/ms.v8i4.850

Katona, G., Sipos, B., Ambrus, R., Csóka, I., & Szabó-Révész, P. (2022). Characterizing the Drug-Release Enhancement Effect of Surfactants on Megestrol-Acetate-Loaded Granules. Pharmaceuticals, 15(2). ttps://doi.org/10.3390/ph15020113

Klojdová, I., Milota, T., Smetanová, J., & Stathopoulos, C. (2023). Encapsulation: A Strategy to Deliver Therapeutics and

Bioactive Compounds? Pharmaceuticals, 16(3), 1–19. https://doi.org/10.3390/ph16030362

Knoth, D., Rincón-Fontán, M., Stahr, P. L., Pelikh, O., Eckert, R. W., Dietrich, H., Cruz, J. M., Moldes, A. B., & Keck, C. M. (2019). Evaluation of a biosurfactant extract obtained from corn for dermal application. International Journal of Pharmaceutics, 564(April), 225–236. https://doi.org/10.1016/j.ijpharm.2019.04.048

Lopedota, A., Denora, N., Laquintana, V., Cutrignelli, A., Lopalco, A., Tricarico, D., Maqoud, F., Curci, A., Mastrodonato, M., la Forgia, F., Fontana, S., & Franco, M. (2018). Alginate-Based Hydrogel Containing Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex for Topical Alopecia Treatment. Journal of Pharmaceutical Sciences, 107(4), 1046–1054. https://doi.org/10.1016/j.xphs.2017.11.016

Mysore, V., Parthasaradhi, A., Kharkar, R., Ghoshal, A., Ganjoo, A., Ravichandran, G., Saraswat, A., Shah, Y., Singh, M., Remadevi, T., & Matte, P. (2019). Expert consensus on the management of androgenetic alopecia in India. International Journal of Trichology, 11(3), 101. https://doi.org/10.4103/ijt.ijt_24_19

Nestor, M. S., Ablon, G., Gade, A., Han, H., & Fischer, D. L. (2021). Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics. Journal of Cosmetic Dermatology, 20(12), 3759–3781. https://doi.org/10.1111/jocd.14537

Ruiz, E., Orozco, V. H., Hoyos, L. M., & Giraldo, L. F. (2022). Study of sonication parameters on PLA nanoparticles preparation by simple emulsion-evaporation solvent technique. European Polymer Journal, 173(May). https://doi.org/10.1016/j.eurpolymj.2022.111307

Salvi, V. R., & Pawar, P. (2019). Nanostructured lipid carriers (NLC) system: A novel drug targeting carrier. Journal of Drug Delivery Science and Technology, 51(990), 255–267. https://doi.org/10.1016/j.jddst.2019.02.017

Srivilai, J., Rabgay, K., Khorana, N., Waranuch, N., Nuengchamnong, N., Wisuitiprot, W., Chuprajob, T., Changtam, C., Suksamrarn, A., Chavasiri, W., Sornkaew, N., & Ingkaninan, K. (2017). Anti-androgenic curcumin analogues as steroid 5-alpha reductase

Downloads

Published

2025-02-25

How to Cite

Jafar, G., Pebriawati, S., Latifah, Z. A., & Pratama, R. (2025). PENGARUH SONIKATOR PROBE TERHADAP FORMULASI NANOSTRUCTURED LIPID CARRIERS KURKUMIN MENGGUNAKAN LIPID PADAT PRECIROL®: EFFECT OF PROBE SONICATOR ON CURCUMIN NANOSTRUCTURED LIPID CARRIERS USING PRECIROL® SOLID LIPIDS. Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-Ilmu Keperawatan, Analis Kesehatan Dan Farmasi, 25(1), 19–28. https://doi.org/10.36465/jkbth.v25i1.1451

Citation Check

Similar Articles

You may also start an advanced similarity search for this article.