Development and Characterization of Effervescent Granules Containing Cinnamomum burmanii Ethanolic Extract with Potent Antioxidant Activity

Authors

  • Rima Rahmawati Universitas Bakti Tunas Husada, Indonesia
  • Rika Yulianti Universitas Bakti Tunas Husada, Indonesia
  • Indra Indra Program Studi S1 Farmasi Universitas Bakti Tunas Husada Tasikmalaya, Indonesia

DOI:

https://doi.org/10.36465/jkbth.v26i1.1805

Keywords:

Cinnamomum burmanii, aktivitas antioksidan, granul effervescent, ekstrak etanol, formulasi nutraseutikal herbal, granulasi basah, minuman fungsional

Abstract

The study aimed to develop effervescent granules containing Cinnamomum burmanii extract with strong antioxidant activity, good physicochemical stability, and consumer acceptability. Ethanolic extraction was employed to maximize the recovery of phenolic and flavonoid compounds, followed by formulation through controlled wet granulation using citric acid, tartaric acid, sodium bicarbonate, polyvinylpyrrolidone, and aspartame. The resulting extract showed potent antioxidant capacity with an IC₅₀ of 7.82 ppm, indicating high radical-scavenging activity. Three formulations (F1–F3) were evaluated for physical properties, dissolution, pH, and sensory characteristics. The optimized formulation (F3) demonstrated rapid effervescence (<3 minutes), suitable acidity (pH 3.7–4.2), low moisture content (<5%), and strong consumer acceptance. Although antioxidant activity slightly decreased after granulation (IC₅₀ ≈ 69 ppm), the product maintained significant efficacy and stability. These results confirm that ethanol extraction combined with optimized wet granulation effectively produces a stable, functional, and palatable herbal effervescent formulation. The study establishes a scientific basis for converting C. burmanii into a modern nutraceutical product and supports its potential application in antioxidant beverages. Future work should explore bioavailability enhancement and synergistic formulations with other botanical extracts to maximize therapeutic value and product performance.

References

Adi‐Dako, O., Kumadoh, D., Egbi, G., Okyem, S., Addo, P. Y., Nyarko, A. K., Osei-Asare, C., Oppong, E. E., & Adase, E. (2021). Strategies for Formulation of Effervescent Granules of an Herbal Product for the Management of Typhoid Fever. Heliyon, 7(10), e08147. https://doi.org/10.1016/j.heliyon.2021.e08147

Akram, M., Rashid, A., Anwar, H., Khan, F. S., Chikwendu, C. J., Destiny, E. C., Dokubo, C. U., Ifeanyi, A., Uche, C. Z., Olisah, M. C., & Egbuna, C. (2023). Exploring the Frontiers of Green Nanotechnology: Advancing Biomedicine, Herbonanoceuticals, Environment, and Sustainability. Scicom J. Med Appl. Med Sci, 2(1), 18–30. https://doi.org/10.54117/sjmams.v2i1.11

AL-Zaydi, M. R. H., Alwan, W. A., Mubder, S. M., Hasan, D., & Jamal, A. (2025). Evaluation Study of the Active Compounds and Antioxidant Activity of Lavender Extract. Academia Open, 10(1). https://doi.org/10.21070/acopen.10.2025.11256

Amaliya, R. (2024). Uji Antioksidan Formulasi Sediaan Granul Effervescent Ektrak Buah Belimbing Wuluh (Averrhoa Bilimbi L.) Dengan Variasi Konsentrasi Asam Dan Basa. Medfarm Jurnal Farmasi Dan Kesehatan, 13(2), 188–196. https://doi.org/10.48191/medfarm.v13i2.341

Aulifa, D. L., Wibowo, D. P., SAFITRI, N., & Budiman, A. (2022). Formulation of Effervescent Granules From Red Ginger (Zingiberis Officinale Roscoe Var. Rubrum) Extract and Its Antioxidant Activity. International Journal of Applied Pharmaceutics, 112–115. https://doi.org/10.22159/ijap.2022v14i1.43377

Bernini, R., Campo, M., Cassiani, C., Fochetti, A., Ieri, F., Lombardi, A., Urciuoli, S., Vignolini, P., Villanova, N., & Vita, C. (2024). Polyphenol-Rich Extracts From Agroindustrial Waste and Byproducts: Results and Perspectives According to the Green Chemistry and Circular Economy. Journal of Agricultural and Food Chemistry, 72(23), 12871–12895. https://doi.org/10.1021/acs.jafc.4c00945

Butar-Butar, M. E. T., Roni, A., Pahlevi, M. R., Zaelani, D., Sagita, N., & Pratama, R. (2025). Recent Advances in Herbal Effervescent Formulations: Challenges and Opportunities. Sciences of Pharmacy, 4(1), 40–50. https://doi.org/10.58920/sciphar0401311

Dai, B., Wang, F., Geng, Y., Chen, C., Zhou, M., & Hang, L. (2024). Study on Preparation Technology and Quality Standard of Acne Granules. Pharmaceutical Fronts, 06(03), e305–e314. https://doi.org/10.1055/s-0044-1789234

Danthanarayana, D. N., & Perera, H. (2024). Investigating the Effect of Fermentation By Lactobacillus Reuteri on Biochemical Properties of Ceylon Cinnamon. International Journal of Pharmacy Practice, 32(Supplement_2), ii65–ii65. https://doi.org/10.1093/ijpp/riae058.077

Divya, R., & Ashok, V. G. (2019). Keep Calm and Eat AAM (Mango): Mangiferin a Miracle Nutraceutical. International Medicine, 1(3), 178. https://doi.org/10.5455/im.48122

EV, F., & Chi, Y. (2016). Mangiferin Modulation of Metabolism and Metabolic Syndrome. Biofactors, 42(5), 492–503. https://doi.org/10.1002/biof.1309

Genskowsky, E., Puente, L., Pérez‐Álvarez, J. Á., Fernández‐López, J., Muñoz, L. A., & Viuda‐Martos, M. (2016). Determination of Polyphenolic Profile, Antioxidant Activity and Antibacterial Properties of Maqui Aristotelia Chilensi (Molina) Stuntz] a Chilean Blackberry. Journal of the Science of Food and Agriculture, 96(12), 4235–4242. https://doi.org/10.1002/jsfa.7628

Hikmawanti, N. P. E., Ramadon, D., Jantan, I., & Mun’im, A. (2021). Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development. Plants, 10(10), 2091. https://doi.org/10.3390/plants10102091

Hussain, Z., Khan, J., Arshad, M. I., Muhammad, F., & Abbas, R. Z. (2021). Comparative Characterization of Cinnamon, Cinnamaldehyde and Kaempferol for Phytochemical, Antioxidant and Pharmacological Properties Using Acetaminophen-Induced Oxidative Stress Mouse Model. Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas, 20(4), 339–350. https://doi.org/10.37360/blacpma.21.20.4.25

Irawan, H., Sari, I. P., Tisnadjaja, D., Ekawati, N., Hertati, A., Novianti, E., & Masaenah, E. (2024). Instant Granule Formulation Combining White Sweet Potato Leaves Extract (Ipomoea Batatas (L.) Lam.) and Javanese Chili (Piper Retrofractum Vahl). Jurnal Sains Natural, 14(1), 36–43. https://doi.org/10.31938/jsn.v14i1.612

Jeong, S. J., Lee, J., & Lee, H. G. (2019). Nanoencapsulation of Synergistic Antioxidant Fruit and Vegetable Concentrates and Their Stability During in Vitro Digestion. Journal of the Science of Food and Agriculture, 100(3), 1056–1063. https://doi.org/10.1002/jsfa.10110

Kementerian Kesehatan Republik Indonesia. (2020). Farmakope Indonesia edisi VI. In Kementerian Kesehatan Republik Indonesia.

Khan, A. (2021). Prediction of Quality Attributes (Mechanical Strength, Disintegration Behavior and Drug Release) of Tablets on the Basis of Characteristics of Granules Prepared by High Shear Wet Granulation. Plos One, 16(12), e0261051. https://doi.org/10.1371/journal.pone.0261051

Kumar, S., Kumari, R., & Mishra, S. (2019). Pharmacological Properties and Their Medicinal Uses of Cinnamomum: A Review. Journal of Pharmacy and Pharmacology, 71(12), 1735–1761. https://doi.org/10.1111/jphp.13173

Lankanayaka, A. A. K., Lakshan, N. D., Jayathunge, L., Bandara, P. C., Manatunga, D. C., & Senanayake, C. M. (2025). A Review of Sustainable Strategies for Encapsulating Antioxidant-Rich Plant Polyphenolic Extracts Using Nanoemulsification to Enhance the Oxidative Stability of Edible Oils. Discover Food, 5(1). https://doi.org/10.1007/s44187-025-00331-8

Liaudanskas, M., Žvikas, V., & Petrikaitė, V. (2021). The Potential of Dietary Antioxidants From a Series of Plant Extracts as Anticancer Agents Against Melanoma, Glioblastoma, and Breast Cancer. Antioxidants, 10(7), 1115. https://doi.org/10.3390/antiox10071115

Liu, J., Luthuli, S., Wu, Q., Wu, M., Choi, J., & Tong, H. (2020). Pharmaceutical and Nutraceutical Potential Applications of Sargassum Fulvellum. Biomed Research International, 2020(1). https://doi.org/10.1155/2020/2417410

Mahyuni, E. L., & Harahap, U. (2024). The Formulation of Effervescent Granules With Oxalis Dehradunensis Raizada Ethanol Extract as an Antioxidant. Journal of Pharmaceutical Sciences and Community, 21(1), 44–50. https://doi.org/10.24071/jpsc.004492

Moharram, B. A., Alburyhi, M. M., Al-Maqtari, T., & Faisal, A. (2025). Evaluating the Antidiabetic Activity of Aloe Niebuhriana Latex in Alloxan‐Induced Diabetic Rats and the Development of a Novel Effervescent Granule‐Based Delivery System. The Scientific World Journal, 2025(1). https://doi.org/10.1155/tswj/5648662

Molyneux, P. (2004). The Use of the Stable Free Radical Diphenylpicryl-hydrazyl (DPPH) for Estimating Antioxidant Activity. Songklanakarin Journal of Science and Technology, 26(December 2003), 211–219. https://doi.org/10.1287/isre.6.2.144

Okoye, C. O., Jiang, H., Wu, Y., Li, X., Gao, L., Wang, Y., & Jiang, J. (2023). Bacterial Biosynthesis of Flavonoids: Overview, Current Biotechnology Applications, Challenges, and Prospects. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.31006

Prasanna, B. L., & Arumugam, V. A. (2019). Cinnamon Species: In Vivo Anti-Oxidant Activity of Ethanolic Extracts of Cinnamon Zeylanicum and Cinnamon Cassicae Barks. Pharmacognosy Journal, 11(2), 245–247. https://doi.org/10.5530/pj.2019.11.38

Rani, K. C., Parfati, N., Ekajayani, N. I., Kurniawan, I. M. A., & Kristiani, N. P. W. (2021). The Development of Moringa Leaves Effervescent Granules With Effervescent Agent of Citric Acid and Sodium Bicarbonate. Pharmaciana, 11(2), 225. https://doi.org/10.12928/pharmaciana.v11i2.20873

Sadman, A. S. M., Samanta, N., Eva, S. A., Alimullah, M., Sultana, S., Ghosh, H. C., Jahan, N., Mandal, S., Banik, R., Ahmed, K. S., Hossain, H., Subhan, N., & Alam, M. A. (2024). HPLC-Analysis of Polyphenolic Compounds in Crateva Nurvala and Evaluation of in Vitro Antioxidant Activities of Its Flash Column Chromatographic Fraction. J. Bio. Exp. Pharm., 2(2), 71–85. https://doi.org/10.62624/jbep00.0019

Sansone, C., & Brunet, C. (2019). Promises and Challenges of Microalgal Antioxidant Production. Antioxidants, 8(7), 199. https://doi.org/10.3390/antiox8070199

Serang, Y., Chen, C., & Lee, M.-J. (2024). Antioxidant Dynamics in Cajanus Cajan (L.) and Melaleuca Leucadendra(L.): From Plants to Nanoparticles. Bio Web of Conferences, 125, 3002. https://doi.org/10.1051/bioconf/202412503002

Sharifi‐Rad, J., Dey, A., Koirala, N., Shaheen, S., Omari, N. E., Salehi, B., Goloshvili, T., Silva, N. C. C., Bouyahya, A., Vitalini, S., Varoni, E. M., Martorell, M., Abdolshahi, A., Docea, A. O., Iriti, M., Călina, D., Les, F., López, V., & Căruntu, C. (2021). Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.600139

Sharma, S. (2025). Antioxidant Activity, Total Phenolic and Total Flavonoid Contents of Whole Plant Extracts Torilis Leptophylla L. Ijrdt. https://doi.org/10.62218/ijrdt.v1i3.115

Verdini, L., Setiawan, B., Sinaga, T., Sulaeman, A., & Wibawan, I. W. T. (2021). Komponen Bioaktif Ekstrak Akuades Kayu Manis (Cinnamomum Burmanii Blume) Asal Sumatra, Indonesia [Bioactive Components of Cinnamon Aquades Extract (Cinnamomum Burmanii Blume) From Sumatra, Indonesia]. Jurnal Teknologi & Industri Hasil Pertanian, 27(1), 24. https://doi.org/10.23960/jtihp.v27i1.24-30

Wahyuni, R. S., Arel, A., & Widya, N. (2024). Antioxidant Activity Test of Cinnamon Root Extract Cinnamomum Burmanii (Nees &Amp; T.Nees) Blume) Based on Solvent Polarity Level. Indonesian Journal of Pharmaceutical Research, 4(2), 1–7. https://doi.org/10.31869/ijpr.v4i2.6265

Wang, Y., Xiao, B. X., Yang, Y., Jiang, S., Xu, L., Lin, X., Nie, X., Chen, J., Chen, Z., & Lin, H.-T. (2025). Antioxidant Profiles of She Medicines: A Comparative Study on Flavonoid and Phenolic Content. Food Science & Nutrition, 13(6). https://doi.org/10.1002/fsn3.70348

Warsinah, W., Nuryanti, N., Utami, E. D., Baroroh, H. N., & Cahyaningrum, P. K. (2025). Antioxidant and Antidiabetic Activities of Cinnamon Bark (Cinnamomum Burmannii) Extracts in Vitro. International Journal of Scientific Research Updates, 9(2), 1–7. https://doi.org/10.53430/ijsru.2025.9.2.0028

Zhang, J., Miao, D., Zhu, W., Xu, J., Liu, W., Kitdamrongtham, W., Manosroi, J., Abe, M., Akihisa, T., & Feng, F. (2017). Biological Activities of Phenolics From the Fruits of Phyllanthus Emblica L. (Euphorbiaceae). Chemistry & Biodiversity, 14(12). https://doi.org/10.1002/cbdv.201700404

Downloads

Published

2026-02-20

How to Cite

Rahmawati, R., Yulianti, R., & Indra, I. (2026). Development and Characterization of Effervescent Granules Containing Cinnamomum burmanii Ethanolic Extract with Potent Antioxidant Activity. Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-Ilmu Keperawatan, Analis Kesehatan Dan Farmasi, 26(1), 84–92. https://doi.org/10.36465/jkbth.v26i1.1805

Issue

Section

Artikel

Citation Check

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)