INOVASI SEDIAAN ORAL FISETIN DENGAN TEKNOLOGI SMART EDIBLE PAPER

Abstract

Fisetin is a flavonoid compound has natural antioxidant, anti-inflammatory and anticancer activities. It has
very low bioavailability and the provision of fisetin in the oral dosage form is very limited. Research has been
carried out to develop and increase solubility and dissolution of fisetin. It was further developed into a solid
oral dosage form of tablets with an edible paper matrix. This study that to develop fisetin into tablet dosage
form with an edible paper matrix, determine the physical quality of tablets and drug release in vitro. Fisetin was
dissolved in a suitable solvent and then poured over an edible paper matrix, dried and cut in 1x1 cm size. Paper
cuttings are printed directly with various compressive strengths of 2, 4 and 6 tons. Tablet physical quality tests
include hardness, disintegration time, friability, weight uniformity, and drug content. Furthermore, dissolution
was tested and the best formula was chosen. The results of this research show that fisetin has the greatest
solubility with DMSO solvent. The edible paper matrix weight is 1000 mg and a tablet weight is 500 mg.
Formula I with a compressive strength of 2 tons is the best formula and meets the physical quality test
requirements of the tablet. The release of formula I (FI) drug was superior (95.20%) and significantly higher
(p<0,05) compared to formula II and III.