PENGGUNAAN ANTI-HIPERTENSI SEBAGAI TERAPI UNTUK HIPERTENSI SELAMA KEHAMILAN : TELAAH PUSTAKA SISTEMATIK

Adila Awaludin, Cherry Rahayu, Neily Zakiyah

Abstract


Resiko komplikasi dan perburukan luaran maternal dan fetal yang terjadi akibat hipertensi selama kehamilan dapat dicegah dengan pengendalian tekanan darah melalui terapi antihipertensi. Tujuan dari studi ini adalah untuk memberikan gambaran penggunaan obat antihipertensi berdasarkan efikasi dan keamanannya pada kasus hipertensi selama kehamilan. Desain studi adalah tinjauan pustaka menggunakan basis data elektronik MEDLINE (PubMed) dan Cochrane Library yang dilakukan hingga Agustus 2021. Strategi pencarian menggunakan kata kunci sesuai dengan topik studi. Artikel diseleksi berdasarkan judul dan abstrak diikuti dengan teks lengkap sesuai kriteria inklusi dan eksklusi. Obat antihipertensi yang dapat digunakan diantaranya IV urapidil, IV dihidralazin, IV urapidil, IV nikardipin, oral metildopa, oral isradipin, oral nifedipin, oral labetalol, oral furosemid, dan oral amlodipin. Urapidil lebih baik dalam mengontrol tekanan darah tinggi dibanding dihidralazin, meskipun efek penurunan tekanan darah yang dihasilkan tidak sekuat nikardipin. Meski demikian, urapidil memiliki tolerabilitas yang lebih baik dibandingkan dengan dihidralazin dan nikardipin. Adapun metildopa tidak memiliki perbedaan yang signifikan dalam efikasi untuk menurunkan tekanan darah dibandingkan dengan labetalol dan isradipin. Terdapat beberapa pilihan obat antihipertensi yang dapat digunakan dan telah dibandingkan dalam percobaan klinis sebagai terapi hipertensi pada kasus hipertensi selama kehamilan.


Keywords


Antihipertensi; hipertensi selama kehamilan; efikasi; keamanan

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References


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DOI: http://dx.doi.org/10.36465/jop.v4i3.787

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