IDENTIFIKASI VARIAN GENETIK TERKAIT KEJADIAN INFARK MIOKARD MELALUI PENDEKATAN BIOINFORMATIK

Rafiastiana Capritasari, Muhammad Irham, Fara Azzahra, Davit Nugraha, Anna Lesmanasari Yusuf, Febriana Astuti, Zulkifli Zulkifli, Anggoro Wicaksono, Andhika Nor Hendryawan, Tiyas Putri Nurgraheni, Kusmini Kusmini, Ilham Alifiar, Dona Suzana

Abstract


Faktor risiko terjadinya penyakit kardiovaskuler selain faktor risiko konvensional (perokok, hipertensi, dislipidemia, diabetes militus dan obesitas) terdapat juga faktor genetik serta faktor risiko non-konvensional seperti kecemasan, stres dan depresi. Tujuan dari penelitian ini yaitu mengidentifikasi variasi genetik yang terkait dengan patogenesis infark miokard pada berbagai populasi dengan menggunakan basis data genom dan pendekatan bioinformatika. Hasil terdapat tiga varian genetik  yaitu gen APOE, ZC3HC1 dan ALDH2  yang memiliki potensi kerusakan terhadap protein DNA sehingga dapat menyebabkan kejadian infark miokard. SNP dengan kode rs7412, rs11556924 dan rs671 merupakan SNP yang paling kuat dikaitkan dengan kejadian infark miokard sehingga dapat direkomendasikan sebagai risiko genetik.


Keywords


Faktor Genetik,Infark Miokard, Single-Nucleotide Polymorphism, Varian Genetik

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References


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DOI: http://dx.doi.org/10.36465/jkbth.v23i1.1307

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