PENGARUH MADU HUTAN TERHADAP KADAR GULA DARAH MENCIT PUTIH (Musmuscullus) JANTAN YANG DIINDUKSI ALOKSAN

Aan Kunaedi, Siska Aprianty, Yuniarti Falya

Abstract


Diabetes is a group of chronic metabolic diseases associated with disorders of carbohydrate, fat and protein metabolism. It is hoped that this research will enable the public and patients suffering from Diabetes Mellitus to use other medicines as alternatives, such as traditional medicines that utilize the natural potential that exists in Indonesia, such as the use of honey, the honey used is taken from the Kuningan area and has not yet been tested for the potential for supportive therapy for DM sufferers. lowers the patient's blood sugar levels. Even though honey contains sugar, people believe that honey can be used as a medicine to lower type 1 and type 2 blood sugar levels, so for this reason it is necessary to scientifically test the potential of honey to reduce blood sugar levels in DM patients. This study aims to determine the effect of honey on the blood sugar levels of male white mice (Mus musculus) induced by alloxan. The research used was an experimental method. The research results show that the difference in antidiabetic effects with the most effectiveness is the positive control (Glibenclamide 0.05%) namely 127.2 mg/dL followed by honey treatment group III (honey 42 mg/20g BW) namely 122.6 mg/dL. Honey has an antidiabetic effect in mice induced by alloxan at a dose of 42mg/20g BW which has the best reducing effect.

Keywords


Diabetes Mellitus, Glibenclamide, Honey

Full Text:

PDF (Indonesian)

References


Adli, farhan kamali. (2020). Open Acces Acces. Jurnal Bagus, 02(01), 402–406.

Amalia, F. (2015). The Effect of Honey in Diabetes Mellitus. J Majority, 4(2), 6–11.

Arifiya, N., & Prasasty, A. T. (n.d.). Analisis Penjualan dan Citra Merek dari 3 Merek Sepeda Motor dengan Metode Anova. 80, 241–246.

BPOM. (2021). Peraturan Badan Pengawas Obat Dan Makanan Nomor 18 Tahun 2021 Tentang Pedoman Uji Farmakodinamik Praklinik Obat Tradisional. Badan Pengawas Obat Dan Makanan RI, 1BPOM. (2021). Peraturan Badan Pengawas Obat Dan Makanan Nomor 18 Tahun 2021 Tentang Pedoman Uji Farmakodinamik Praklinik Obat Tradisional. Badan Pengawas Obat Dan Makanan RI, 1, 15–24., 15–24.

Fajarnata, E. (2015). PERBANDINGAN EFEKTIVITAS BEBERAPA PRODUK OBAT PATEN METFORMIN PADA MENCIT (Mus Musculus) JANTAN GALUR WISTAR (pp. 1–46).

Fernanda, S. I., Ratnawati, D. E., & Adikara, P. P. (2017). Identifikasi Penyakit Diabetes Mellitus Menggunakan Metode Modified K- Nearest Neighbor ( MKNN ). Jurnal Pengembangan Teknologi Informasi Dan Ilmu Komputer, 1(6), 507–513.

Fraksi, S., Dari, A. I. R., & Ketan, B. (2017). 1* , 1 , 2. 18(1).

Gumantara, M. P. B., & Oktarlina, R. Z. (2017). Perbandingan Monoterapi dan Kombinasi Terapi Sulfonilurea-Metformin terhadap Pasien Diabetes Melitus Tipe 2. Majority, 6(1), 55–59.

Hikmah, N., & Khaerati, K. (2016). PENGARUH PEMBERIAN EKSTRAK DAUN SALAM (Syzygium polyanthum Wight.) TERHADAP GLIBENKLAMID DALAM MENURUNKAN KADAR GLUKOSA DARAH MENCIT(Mus musculus) YANG DIINDUKSI ALOKSAN THE IMPACT OF ADMINISTRATION BAY LEAF EXTRACT (Syzygium polyanthum Wight.) ON GLIBENC. Galenika Journal of Pharmacy 24 Journal of Pharmacy, 2(1), 24–30.Hutapea, E. E., Musfiroh, I., Studi, P., Apoteker, P., Farmasi, F., & Padjadjaran, U. (2021). Farmaka Farmaka. Farmaka, 18, 53–59.

Intan, P. R., & Khariri. (2020). Pemanfaatan Hewan Laboratorium Yang Sesuaiuntuk Pengujian Obat dan Vaksin. Prosiding Seminar Nasional Biologi Di Era Pandemi COVID-19, 6(1), 48–53.

Irdalisa, Safrida, Khairil, Abdullah, & Sabri, M. (2015). Profil Kadar Glukosa Darah Pada Tikus Setelah Penyuntikan Aloksan Sebagai Hewan Model Hiperglikemik. Jurnal Edubio Tropika, 3(1), 25–28.

Keperawatan, J., Kesehatan, D., Febriyanti, A., Cau, ), Jiu, K., & Aryanti, S. (n.d.). EFEKTIVITAS JENIS-JENIS MADU (MADU HUTAN, MADU KELULUT DAN MADU TERNAK) TERHADAP KADAR GULA DARAH.

http://jurnal-stikmuh-ptk.id

Khasanah, R., Parman, S., & Suedy, S. W. A. (2017). Kualitas Madu Lokal Dari Lima Wilayah Di Kabupaten Wonosobo. Jurnal Biologi, 6(1), 29–37.

Lestari, Zulkarnain, & Sijid, S. A. (2021). Diabetes Melitus: Review Etiologi, Patofisiologi, Gejala, Penyebab, Cara Pemeriksaan, Cara Pengobatan dan Cara Pencegahan. UIN Alauddin Makassar, November, 237–241. http://journal.uin-alauddin.ac.id/index.php/psb

Madu, K., Spesies, D., Penghasil, L., Kehutanan, P. S., Pertanian, F., & Jambi, U. (2022). Kualitas madu dari 3 spesies lebah penghasil madu. 6(1), 43–50.

Mangkuliguna, G., & Kuatama, R. (2021). 1-hydroxymethyl Harmine- TGFβSF Inhibitor : Inovasi Terapi Diabetes Melitus Terbaru Melalui Inisiasi Proses Regenerasi Sel β Pankreas p ada Penderita DM Tipe 1 dan 2 mematikan menurut World Health Organization karena telah menyebabkan. 2(2), 104–115.

Mutiarahmi, C. N., Hartady, T., & Lesmana, R. (2021). Use of Mice As Experimental Animals in Laboratories That Refer To the Principles of Animal Welfare: a Literature Review. Indonesia Medicus Veterinus, 10(1), 134–145. https://doi.org/10.19087/imv.2020.10.1.134

Nugraha, dkk. (2018). Review Artikel: Metode Pengujian Aktivitas Antidiabetes. 16, 28–34.

Nurul Afifah, H. (2016). Mengenal Jenis-Jenis Insulin Terbaru untuk Pengobatan Diabetes. Farmasetika.Com (Online), 1(4), 1. https://doi.org/10.24198/farmasetika.v1i4.10367

Petersmann, A., Nauck, M., Müller-Wieland, D., Kerner, W., Müller, U. A., Landgraf, R., Freckmann, G., & Heinemann, L. (2018). Definition, classification and diagnostics of diabetes mellitus. Journal of Laboratory Medicine, 42(3), 73–79. https://doi.org/10.1515/labmed-2018-0016




DOI: http://dx.doi.org/10.36465/jop.v6i2.1208

Refbacks

  • There are currently no refbacks.


Copyright (c) 2024 Aan Kunaedi, Siska Aprianty, Yuniarti Falya

p-ISSN: 2620-8563; e-ISSN: 2621-1521


Index:

RJI Main logo